What is the difference between MAO-A and MAO-B?

What is the difference between MAO-A and MAO-B?

Differences between MAOA and MAOB Monoamine oxidase A (MAOA) generally metabolizes tyramine, norepinephrine (NE), serotonin (5-HT), and dopamine (DA) (and other less clinically relevant chemicals). In contrast, monoamine oxidase B (MAOB) mainly metabolizes dopamine (DA) (and other less clinically relevant chemicals).

What is the function of MAO-A?

Specifically, monoamine oxidase A is involved in the breakdown of the neurotransmitters serotonin, epinephrine, norepinephrine, and dopamine. Signals transmitted by serotonin regulate mood, emotion, sleep, and appetite. Epinephrine and norepinephrine control the body’s response to stress.

What are the types of MAO?

In humans there are two types of MAO: MAO-A and MAO-B.

• Both are found in neurons and astroglia.
• Outside the central nervous system: MAO-A is also found in the liver, pulmonary vascular endothelium, gastrointestinal tract, and placenta. MAO-B is mostly found in blood platelets.

What does Mao-a metabolise?

Monoamine oxidases (MAO) are FAD-dependent enzymes that catalyze the oxidative deamination of structurally diverse amines Kalgutkar et al (2001). MAO also metabolizes trace amines (e.g., phenylethylamine and tyramine).

What is COMT and Mao?

Two major enzymes are responsible for catecholamine catabolism in the brain: catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA). The transcriptional activity of the genes coding for these enzymes is governed by common functional polymorphisms.

Is serotonin a monoamine?

Monoamines refer to the particular neurotransmitters dopamine, noradrenaline and serotonin.

Does everyone have COMT?

Everyone carries two copies of the COMT gene, one inherited from each parent. The study showed that people with two copies of the “met” form of the COMT gene had a much more pronounced response to pain than those who carried two copies of the “val” form of the gene.

What are monoamine oxidases (MAOs)?

Monoamine oxidases (MAOs) catalyze the breakdown of monoamine neurotransmitters including dopamine, serotonin, and epinephrine in the CNS (Cai, 2014 ).

What is the ideology of Maoism?

Maoism, on the other hand, is also known by the name of Mao Zedong Thought. Mao Zedong was the Chinese leader who came up with this ideology. Actually, Mao Zedong wanted his country, China, to see a proletariat revolution to change the society at that time.

What is the function of the MAOA enzyme?

The main role for the monoamine oxidase ( MAOA) enzyme is thought to be in degrading serotonin following its reuptake from the synaptic cleft, although it is also capable of degrading both norepinephrine and dopamine.

Does MAOA deficiency promote aggression?

A role for MAOA deficiency in promoting aggression is further supported by studies on mutant mice that had deletions of portions of their monoamine oxidase gene, resulting in the lack of enzyme activity in the brain and liver.