How is lupus nephritis treated in pregnancy?
How is lupus nephritis treated in pregnancy?
Immunosuppressive Therapy
- Corticosteroids. Their efficacy in the management of LN is well established, and prednisone and prednisolone are appropriate for continued use throughout pregnancy.
- Hydroxychloroquine.
- Azathioprine.
- Calcineurin Inhibitors.
- Intravenous Ig.
- Mycophenolate Mofetil.
- Cyclophosphamide.
- Rituximab.
How to treat lupus when pregnant?
EULAR guidelines recommend hydroxychloroquine (HCQ) be taken preconceptionally and throughout pregnancy to control disease activity. HCQ, oral glucocorticoids, azathioprine, cyclosporine, and tacrolimus can be used to prevent or manage SLE flares during pregnancy.
What are the maternal& fetal effects of SLE?
Women with SLE also had a two- to fourfold increased rate of obstetric complications including preterm labor, unplanned cesarean delivery, fetal growth restriction, preeclampsia, and eclampsia. Patients with SLE also had a significantly higher risk of thrombosis, infection, thrombocytopenia, and transfusion.
Can I give birth with lupus?
Women with lupus can safely get pregnant and most will have normal pregnancies and healthy babies. However, all women with lupus who get pregnant are considered to have a “high risk pregnancy.” This means that problems during pregnancy may be more likely for women with lupus.
Does lupus cause miscarriage?
Women with lupus are at higher risk for miscarriage and other complications during pregnancy. This is partly because lupus can cause health problems, such as kidney disease, high blood pressure and antiphospholipid antibodies (like lupus anticoagulants) that may increase the risk of a pregnancy loss.
Can I have a healthy baby with lupus?
Can SLE cause miscarriage?
Our results suggested that pregnancy during an active SLE phase was more likely to lead to pregnancy loss (including miscarriage, stillbirth, and neonatal death), premature birth, IUGR, and low birth weight.
Can pregnancy trigger autoimmune?
In some cases, pregnancy may have a profound effect on the symptoms of autoimmune diseases, such as in the case of Rheumatoid arthritis and multiple sclerosis. Pregnancy may trigger an autoimmune disorder. An existing autoimmune disorder can interfere with pregnancy, causing harm to the fetus.
Can lupus cause birth defects?
Most lupus patients give birth to healthy babies. Babies born to lupus patients have no greater chance of birth defects or mental retardation than those born to women without lupus. Among lupus patients with anti-Ro/SSA or anti-La/SSB antibodies, the risk that the baby will have neonatal lupus erythematosus is 25%.
