Should I give my dog Trilostane?
Should I give my dog Trilostane?
Trilostane is reported to be safe and effective in the treatment of pituitary-dependent hyperadrenocorticism (HAC), adrenal-dependent HAC, and alopecia X.
Is Trilostane hazardous?
Causes skin irritation. Material may be irritating to the mucous membranes and upper respiratory tract. May be harmful by inhalation, ingestion, or skin absorption. May cause respiratory system irritation.
Can Trilostane cause Addison’s?
This case showed how important it is to monitor the treatment of hyperadrenocorticism with trilostane and also that even very brief therapy may lead to persistent Addison’s disease probably caused by irreversible lesions in the adrenal glands.
How long does it take Trilostane to work in dogs?
Trilostane is given orally (by mouth) in the form of capsules. It should be given with food, and preferably in the morning if once daily dosing. This medication should take effect within 1 to 2 days.
How does Trilostane work in dogs?
Trilostane is a synthetic enzyme inhibiting drug that is used to treat Cushing’s disease in dogs and cats. Trilostane decreases the production of excessive cortisol hormone by the adrenal gland. This disease is not cured by trilostane but can be managed successfully.
How long does it take for trilostane to work in dogs?
Pharmacokinetic studies in healthy dogs showed that maximal plasma concentration of trilostane occurs 1.7 to 3.8 h following administration and plasma concentration returns to baseline by about 12 h [Vetoryl (trilostane) 2015 drug insert, Dechra Veterinary Products, Pointe-Claire, Quebec].
How many milligrams of trilostane are in a capsule?
Trilostane is now supplied in 5-, 10-, 30-, 60-, and 120-mg capsules (Vetoryl). Currently, the manufacturer’s initial dose recommendation for trilostane is 2.2 to 6.6 mg/kg BW, PO, q24h based on body weight and capsule size.
Does trilostane have a positive effect on dogs with PDH?
This study suggests that withholding treatment for dogs with PDH could increase the risk of death. Therefore, it suggests a positive effect of trilostane in dogs with PDH.
Is trilostane or mitotane better for dogs with HAC?
However, the veterinary literature is lacking large prospective, randomized, controlled studies comparing trilostane and mitotane therapy to determine which is the superior treatment for dogs with HAC. Many research articles detailing the use of trilostane in dogs with HAC have been published.
