What is CENP antibody?

What is CENP antibody?

Anti-SS-B and anticentromere protein (CENP) antibodies are used for the diagnosis of systemic lupus erythematosus, Sjögren’s syndrome, and systemic sclerosis. However, autoantibody production has also been reported in patients with various malignancies [2–10].

What does CENP B positive mean?

Anti-centromere antibody (ACA) have been recognized in sera of patients with primary biliary cirrhosis (PBC) and CREST syndrome. The major reactive antigen of ACA have been identified as CENP-B (80kDa).

What is anti centromere protein B?

Abstract. Centromere protein B (CENP-B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often those with scleroderma).

What is limited cutaneous systemic sclerosis?

Limited cutaneous systemic sclerosis is a subtype of systemic sclerosis characterized by the association of Raynaud’s phenomenon and skin fibrosis on the hands, face, feet and forearms.

What does centromere antibody positive mean?

A positive test for centromere antibodies is strongly associated with CREST syndrome. The presence of detectable levels of centromere antibodies may antedate the appearance of diagnostic clinical features of CREST syndrome by several years.

What is the significance of anti-centromere antibodies?

Anti-centromere antibodies present early in the course of disease and are notably predictive of limited cutaneous involvement and a decreased likelihood of aggressive internal organ involvement, such as fibrosis in the lungs.

What is CENP in centromere?

CENPA is a protein which epigenetically defines the position of the centromere on each chromosome, determining the position of kinetochore assembly and the final site of sister chromatid cohesion during mitosis. In most eukaryotes CENPA is loaded into large domains of highly repetitive satellite DNA.

What does CENP a stand for?

Human centromere protein A (CENP-A) can replace histone H3 in nucleosome reconstitution in vitro | PNAS.

Do proteins act as antibodies?

Antibodies are proteins made by B cells, part of the body’s immune system. The normal function of antibodies is to latch onto foreign substances (antigens) and flag them for destruction, thus helping to fight infection.

Are antibodies protein specific?

Antibodies work by recognising and sticking to specific proteins, such as those found on the surfaces of viruses and bacteria, in a highly specific way. When the body encounters a microbe for the first time, immune cells produce antibodies that specifically recognise proteins associated with that particular microbe.

Is an antibody a protein?

Antibodies are large Y-shaped proteins. They are recruited by the immune system to identify and neutralize foreign objects like bacteria and viruses. Each antibody has a unique target known as the antigen present on the invading organism. This antigen is like a key that helps the antibody in identifying the organism.