What does the ATF3 gene do?
What does the ATF3 gene do?
ATF3 functions as an oncogene or tumor suppressor in prostate cancer. ATF3 may be upregulated by androgen, thus induces cell proliferation and G1-to-S-phase transition of the cell cycle. In addition, ATF3 SUMOylation enhanced cyclin D1 (CCND1) activation, resulting in increased cell proliferation and colony formation.
What is ATF4 gene?
ATF4 (Activating Transcription Factor 4) is a Protein Coding gene. Diseases associated with ATF4 include Coffin-Lowry Syndrome and Leukoencephalopathy With Vanishing White Matter. Among its related pathways are CREB Pathway and ERK Signaling.
How can activating a transcription factor cause long term cellular changes?
The transcription factors are the accessory protein. The activating factor leads to activate the transcription of DNA. Due to this, the changes of genes take place. It may severely damage the cells or long-term cellular changes.
What activates ATF4?
Cellular Nutrient Utilization and Cancer ATF4 expression is stimulated in response to amino acid deprivation via General Control Nonderepressible-2 (GCN2) and during ER stress and unfolded protein response (UPR) via protein kinase R-like ER kinase (PERK).
How do transcription factors play a role in a cellular response to signaling?
Gene expression. Many signaling pathways cause a cellular response that involves a change in gene expression. Transcription makes an RNA transcript (copy) of a gene’s DNA sequence. Translation reads information from the RNA and uses it to make a protein.
How does ATF4 induce apoptosis?
Results: ATF4 mRNA and protein expression levels were higher after radiation and increased in a dose- and time-dependent manner in AHH1 lymphoblast cells (P < 0.05). These findings suggest that ATF4 may play a role in radiation-induced cell killing by inhibiting cell proliferation and promoting cell apoptosis.
What is a transcription factors in cell signaling?
Browse transcription factors pathways Transcription factors are DNA-binding proteins that regulate the expression of genes. In the process, they can increase or decrease the level of transcription of specific genes.
What does a transcription factor do in a signal transduction pathway?
Signal transduction pathways regulate gene expression by modulating the activity of nuclear transcription factors. The mechanisms that control the activity of two groups of sequence-specific transcription factors, the AP-1 and CREB/ATF proteins, are described.
Why would a signaling pathway need to be regulated quizlet?
Why would a signaling pathway need to be regulated? Short-term and long-term changes occur as a response to the cell’s environment, which is always subject to change. A cell must regulate with pathways are on/off in order to appropriately respond to its environment.
What is the role of ATF3 in the Arg/N-degron pathway?
The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway. The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death. The mRNA levels of heat shock factor 1 are regulated by thermogenic signals via the cAMP-dependent transcription factor ATF3.
What is the role of ATF3 in the pathophysiology of macrophage migration?
ATF3 promotes macrophage migration and reverses M1polarized macrophages to the M2 phenotype by upregulation of TNC via the Wnt/betacatenin signaling pathway. Microglia make contact through unknown neuronal signals regulated by ATF3 in hypoglossal nucleus.
What is the role of activating transcription factor 3 (Atf3)?
Loss of activating transcription factor 3 (ATF3) in knockout mice promotes the emergence of keratins CK5+CK8+ epithelial cells. A novel role for ATF3 in the inhibition of lipopolysaccharide-induced TNF-alpha and in the impairment of monocyte and macrophage migration, is reported.
What is the role of ATF3 in the pathogenesis of tuberculosis?
Activating transcription factor 3 modulates the macrophage immune response to Mycobacterium tuberculosis infection via reciprocal regulation of inflammatory genes and lipid body formation. The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway.
