What is tacrolimus trough?

What is tacrolimus trough?

The tacrolimus test is used to measure the amount of the drug in the blood to determine whether the concentration has reached a therapeutic level and is below the toxic level.

What is the normal range of tacrolimus level?

The general therapeutic range for tacrolimus is 5-20 ng/mL.

What is a toxic tacrolimus level?

The highest mean plasma and whole-blood tacrolimus levels during the toxic episodes were 2.7 ± 0.8 ng/ml (range 1.1–3.5) and 31.6 ± 10.6 ng/ml (range 14.5–50.5), respectively. The drug levels were considered to be beyond the therapeutic range in 18/22 (82%) patients.

What do tacrolimus levels tell you?

Tacrolimus can cause kidney damage, especially in high doses. Measuring levels in people who have had a kidney transplant may help to distinguish between kidney rejection (levels in the blood are low) and kidney damage due to tacrolimus toxicity (levels in the blood are high).

What causes tacrolimus levels to drop?

*Conclusions: Low tacrolimus trough levels (<3.5 ng / ml), are related to changes of brands and greater variability of the trough levels. These trough levels are related to acute rejection and short-term creatinine duplication.

What is a normal tacrolimus level after kidney transplant?

The Kidney Disease: Improving Global Outcomes guidelines suggest that 5–15 ng/mL of TAC trough levels should be maintained during the first 2–4 months post-transplant and then reduced in stable KTRs to minimize toxicity, with a low quality of evidence [21].

What is tacrolimus levels in renal transplant?

Patients who receive IL-2 receptor blockade require tacrolimus levels of 10 to 15 ng/ml for only the first 6 wk after transplantation, followed by levels of 5 to 10 ng/ml thereafter (78).

What are the side effects of too much tacrolimus?

Commonly reported side effects of tacrolimus include: opportunistic infection, diabetes mellitus, infection, headache, hyperglycemia, hyperkalemia, increased blood urea nitrogen, increased serum creatinine, mental status changes, nephrotoxicity, sensation disorder, and tremor.

What affects tacrolimus?

After adjusting for sex, body-weight and doses of corticosteroids and mycophenolate mofetil, we noted that CYP3A5 genotypes had the most profound effect on the dose and dose-adjusted trough levels of tacrolimus 1-5 years after transplantation (p < 0.001).

When do you draw tacrolimus troughs?

For cyclosporine or tacrolimus trough-level monitoring, blood should be drawn 12 h after the last dose (i.e., immediately before the next dose).

How do you adjust tacrolimus levels?

Prograf® (tacrolimus) Post operatively, the oral dose will be 0.07 mg/kg/dose BID adjusted subsequently to achieve target levels. Patients should be NPO 1 hour before and after Prograf dosing. If levels are persistently towards the lower end of the target range, consider 20% dose increase.

What happens if my tacrolimus level is low?

Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.

Post liver transplant, the Tacrolimus (tac) levels are usually maintained in range of 3.6 – 14 ng/ml. So, a level of 11.1 is normal, however, please consult your doctor regarding this.

How often to check tacrolimus level?

It is usually taken twice a day. Space your doses 12 hours apart, and take tacrolimus at the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

When to obtain tacrolimus levels?

Tacrolimus is usually taken twice a day at set intervals before or after meals. When a person takes a dose, blood concentrations rise and peak within about 2 to 3 hours and then begin to slowly drop. The blood test is usually measured as a ‘trough’ level.

When to draw tacrolimus levels?

In current clinical practice, whole blood levels are monitored using immunoassay methods. Blood trough levels of tacrolimus should be monitored during the post-transplantation period. When dosed orally, blood trough levels should be drawn approximately 12 hours post-dosing, just prior to the next dose.