What is Tn in cancer?
What is Tn in cancer?
Expression of Tn antigen is a prognostic factor for overall and relapse-free survival in lung adenocarcinoma (5) and correlates with metastatic potential in colorectal cancer (6). Tn antigen is made up of one N-acetylgalactosamine (GalNAc) monosaccharide and represents the initiation of mucin-type O-glycosylation.
What is sialyl TN?
Introduction. Sialyl-Tn (STn) is a carbohydrate antigen discovered as a cancer marker in the early 80s. Detected in virtually all epithelial cancers investigated, STn has known a 20 years long golden age as a research topic with two main focuses.
Is sialic acid an HMO?
Sialic acid is not only a component of HMOs but is also very important in brain development [3]. The most abundant HMO in breast milk of about 80% of all women is 2′-FL, which constitutes up to 30% of the total HMOs [4]. There are also wide differences in the production of HMOS by individual women.
Do eggs have Neu5Gc?
As predicted from prior work (33), poultry and eggs do not contain Neu5Gc and fruits and vegetables do not contain any sialic acids. Although the CMAH gene is present in fish, none of the seafood sampled contains significant amounts of Neu5Gc (with the exception of caviar).
What foods contain sialic acid?
Dietary sources that are rich in Neu5Gc include red meats such as beef, pork, lamb, and to a much lesser degree, cow’s milk products.
Does sialic acid signal to immune cells?
Sialic acids can modulate the immune system in diverse ways through Siglecs, influence on antibody mediated clearance of pathogens and through complement. Sialylation of the antibody immunoglobulin A (IgA) interferes with the cell surface attachment of influenza A and mediates anti-viral activity of IgA (40).
What is the significance of sialic acid?
Sialic acids (Sias) are nine-carbon atoms sugars usually present as terminal residues of glycoproteins and glycolipids on the cell surface or secreted. They have important roles in cellular communication and also in infection and survival of pathogens.
What is onco-foetal sialyl-Tn (STn) antigen?
Activation of an aberrant glycosylation pathway in cancer cells can lead to expression of the onco-foetal sialyl-Tn (sTn) antigen. STn is a truncated O-glycan containing a sialic acid α-2,6 linked to GalNAc α-O-Ser/Thr and is linked with an adverse outcome and poor prognosis in cancer patients.
Is the sialyl-Tn-antigen involved in carcinogenesis?
As the sTn-antigen is expressed early in carcinogenesis targeting sTn in cancer may enable the targeting of tumours from the earliest stage. Keywords: COSMC; O-glycans; ST6GalNAc1; cancer; glycosylation; sialyl-Tn.
What is STN in oglycan?
STn is a truncated O-glycan containing a sialic acid α-2,6 linked to GalNAc α-O-Ser/Thr and is linked with an adverse outcome and poor prognosis in cancer patients. The … The Role of Sialyl-Tn in Cancer Int J Mol Sci. 2016 Feb 24;17(3):275.doi: 10.3390/ijms17030275. Author Jennifer Munkley 1
