How is daptomycin metabolized?
How is daptomycin metabolized?
Daptomycin is primarily renally excreted, with the majority of the drug remaining intact in the urine. Since daptomycin is excreted through the kidneys, the dosing interval is increased to every 48 h in patients with severe renal impairment defined as a creatinine clearance of <30 mL/min.
Where is daptomycin metabolized?
Daptomycin
| Clinical data | |
|---|---|
| Metabolism | Renal (speculative) |
| Elimination half-life | 7–11 hours (up to 28 hours in renal impairment) |
| Excretion | Renal (78%; primarily as unchanged drug); faeces (5.7%) |
| Identifiers |
What is the half-life of daptomycin?
Half-life: 8 to 9 hours in healthy adults with normal renal function. The elimination half-life can be significantly prolonged in patients with renal impairment (up to 28 hours).
Is daptomycin concentration or time dependent?
Daptomycin is the first member of the novel cyclical- lipopeptide class, which provides rapid, concentration-dependent bactericidal activity against a broad range of gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) (2, 6, 9, 10).
Does daptomycin penetrate CSF?
After correcting for daptomycin protein binding, the penetration of daptomycin into the CSF was determined to be 11.5% (21).
Is daptomycin nephrotoxic?
Our analysis suggests that daptomycin is a less nephrotoxic agent than vancomycin. These results are in agreement with previous observations [23, 24]. In a randomized trial, Fowler et al.
Is daptomycin inactivated by surfactant?
Importantly, daptomycin must not be used for the treatment of pneumonia or empiric therapy when pneumonia is in the differential diagnosis (even when caused by a susceptible organism) because daptomycin penetrates lung tissue poorly and is inactivated by pulmonary surfactant.
What is the pH of daptomycin?
The pH of the solution upon reconstitution is 6.8. Freshly reconstituted solutions of CUBICIN RF range in color from pale yellow to light brown.
How long does it take to infuse daptomycin?
In adults, Daptomycin is given by intravenous infusion (see section 6.6) and administered over a 30-minute period or by intravenous injection (see section 6.6) and administered over a 2-minute period.
How is daptomycin dosed?
Dosage In Adults For cSSSI Administer CUBICIN 4 mg/kg to adult patients intravenously in 0.9% sodium chloride injection once every 24 hours for 7 to 14 days.
Is linezolid time-dependent or concentration dependent?
Time-dependent antibiotics. Left: Time-dependent antibiotics (beta-lactams, including penicillins and penems, glycopeptides, linezolid, macrolides, etc.). The time that the concentration of a drug remains above the MIC (T > MIC) is the PK-PD index correlating with efficacy.
Does ceftaroline penetrate the CNS?
Although CPT does not have an FDA-approved indication for CNS infections, there is significant interest in exploring its utility for this indication. CPT has the potential for use in CNS infections based on its penetration of ~15% into inflamed meninges in animal models.
What is the efficacy of daptomycin in the treatment of bacteremia?
In a clinical study in patients with bacteremia, 16% of daptomycin-treated patients and 10% of patients receiving a comparator anti-infective (vancomycin or a penicillinase-resistant penicillin) had persisting or relapsing S. aureus infections. In vitro studies indicated reduced susceptibility to daptomycin developed during or following treatment.
When to discontinue daptomycin due to high CK levels?
Discontinue daptomycin in patients with unexplained signs or symptoms of myopathy in conjunction with increases in CK >1000 U/L (i.e., approximately 5 times ULN) or in patients without reported symptoms who have substantial increases in serum CK concentrations (i.e., >2000 U/L [≥10 times ULN]). 1 23 24 25
What are the contraindications for Daptomycin?
Daptomycin is not indicated for the treatment of pneumonia or left-sided infective endocarditis due to S. aureus. Use is not recommended in pediatric patients younger than one year of age due to the risk of potential effects on muscular, neuromuscular, and/or nervous systems (either peripheral and/or central). 21
How deep does daptomycin penetrate tissue?
Daptomycin. The degree of tissue penetration, defined as the ratio of the area under the free drug concentration-time curve for tissue to that for plasma, was similar. Daptomycin at 4 mg/kg penetrated well into the soft tissue, reaching concentrations approximately 70 to 90% of those of the free drug in plasma.
