What is hepatitis genotype?

What is hepatitis genotype?

A genotype is a way to put the hepatitis C virus (HCV) into categories based on similar genes. It’s important to know and understand HCV genotypes because different genotypes respond differently to medicines that treat and cure HCV. HCV has six genotypes, labeled 1 through 6.

Which HCV genotype is common in Pakistan?

In Pakistan, the most predominant HCV genotype is 3a and 3b followed by 1a, 2a, and untypable genotype (6,7,18,37). In Khyber Pakhtunkhwa (KPK), Punjab, and Sindh, genotype 3a and 3b were found to be most prevalent, whereas most of the patients from Baluchistan were infected with genotype 1a and 2a (37).

What kind of drug is Simeprevir?

Simeprevir is used along with ribavirin (Copegus, Rebetol) and peginterferon alfa (Pegasys) to treat chronic hepatitis C (an ongoing viral infection that damages the liver). Simeprevir is in a class of medications called protease inhibitors. It works by decreasing the amount of hepatitis C virus (HCV) in the body.

What is the most common HCV genotype in Jordan?

Sub-genotype analysis revealed a large genetic diversity of HCV in Jordan with sub-genotypes 4c/d, 1a and 1b being the most common.

What are the genotype types?

A description of the pair of alleles in our DNA is called the genotype. Since there are three different alleles, there are a total of six different genotypes at the human ABO genetic locus. The different possible genotypes are AA, AO, BB, BO, AB, and OO.

How much does Simeprevir cost?

Cost and Medication Access The cost for a 28-days supply of simeprevir is $22,120 and a 12-week supply is $66,360. Thus, a typical 12-week treatment course of simeprevir when used with a total of 24-weeks of peginterferon plus ribavirin will cost approximately $85,000.

Who makes Simeprevir?

OLYSIO™ (simeprevir) is an NS3/4A protease inhibitor jointly developed by Janssen R&D Ireland and Medivir AB and indicated in the U.S. for the treatment chronic hepatitis C infection in combination with pegylated interferon and ribavirin in HCV genotype 1 infected subjects with compensated liver disease, including …

Which genotype has the strongest immunity?

The GG genotype of SP induced stronger immune responses than those of the other two genotypes in the pattern recognition molecule and immune-responsive effector pathways. These findings demonstrated the population variations of RSV during the circulation between the vector insect and host plant.

What is the mechanism of action of simeprevir?

Class and Mechanism. Simeprevir is a NS3/4A hepatitis C virus (HCV) protease inhibitor. Simeprevir is a macrocyclic compound that non-covalently binds to and inhibits the NS3/4A HCV protease, a protein that is responsible for cleaving and processing the HCV-encoded polyprotein, a critical step in HCV viral life cycle.

When was simeprevir approved for hepatitis C?

On November 5, 2014, the U.S. FDA approved the use of simeprevir in combination with sofosbuvir for patients with genotype 1 chronic hepatitis C. Simeprevir is indicated as a component of combination antiviral treatment for patients with chronic hepatitis C genotype 1 infection.

What are the most common mutations associated with simeprevir treatment failure?

The most common mutations were at the NS3 positions: Q80, S122, R155, and D168. Overall, the most common mutations to emerge with treatment failure were D168V and R155K. For genotype 1a, the most common mutation to emerge with simeprevir treatment failure is the R155K mutation (alone or in combination with mutations at codons Q80, S122, and D168).

Can simeprevir and ribavirin be taken together?

Most experts recommend not using simeprevir in combination with peginterferon plus ribavirin if the patient has a baseline Q80K polymorphism at baseline. The Q80K mutation does not appear to significantly impact the treatment response with simeprevir plus sofosbuvir, with or without ribavirin.