What is eosinophilic granuloma?

What is eosinophilic granuloma?

Eosinophilic granuloma is a rare, benign tumor-like disorder characterized by clonal proliferation of antigen-presenting mononuclear cells of dendritic origin known as Langerhans cells 2).

What is the prevalence of eosinophilic granuloma (Langerhans cell histiocytosis)?

Eosinophilic granuloma (Langerhans cell histiocytosis) is rare. It occurs in 1 to 2 newborns per million per year. The incidence in children < 15 years is 4 to 5 cases per million per year. In adults, eosinophilic granuloma (Langerhans cell histiocytosis) is about 1 to 2 cases per million per year.

What are the treatment options for eosinophilic granulomatosis with polyangiitis?

Treatment may involve the use of glucocorticoids (steroids) and/or other immunosuppressive therapies. [1] [2] [3] As of December 2017, mepolizumab (Nucala) became the first therapy approved specifically to treat eosinophilic granulomatosis with polyangiitis.

What are the symptoms of eosinophilic dermatitis?

Skin symptoms: About half of affected people may develop skin abnormalities such as purplish skin lesions, a rash with hives, and/or small bumps (especially on the elbows) due to accumulation of eosinophils in skin tissue.

Eosinophilic granuloma is a variety of histiocytosis-X with unknown etiology. Eosinophilic granuloma occurs as single or multiple lesions of bone destruction. It is seen more commonly in children or young adults although it may be found at all ages.

How is eosinophilic granuloma treated?

Treatment for eosinophilic granuloma depends on several factors and usually includes a combination of surgery, chemotherapy, radiation therapy, and corticosteroids. However, for some patients, close observation alone may be the appropriate course of action.

How do you treat eosinophilic granuloma complex in cats?

“Corticosteroids are the most common treatment to control the symptoms of eosinophilic granuloma complex.” Corticosteroids are the most common treatment to control the symptoms of eosinophilic granuloma complex.

What does eosinophilic granuloma look like?

Eosinophilic granulomas are raised, circular, yellowish to pink nodules. They may be found anywhere on the body but are most common on the head, face, bridge of the nose, ears, paw pads, lips, chin, mouth, and thighs. Linear lesions are found most often on the thighs but have been seen on other body locations.

Is eosinophilic granuloma a tumor?

Eosinophilic granuloma is a rare, benign tumor-like disorder characterized by clonal proliferation of antigen-presenting mononuclear cells of dendritic origin known as Langerhans cells [1, 2].

Can an eosinophilic granuloma come back?

While recurrence is always possible, many cases of eosinophilic granuloma do not come back. Research suggests that the condition has a recurrence rate of less than 20%, meaning that tumors do not come back in over 80% of cases of eosinophilic granuloma.

Is eosinophilic granuloma complex painful?

In cats, three diseases have been grouped in this complex. Eosinophilic ulcers (also called “rodent ulcers” or indolent ulcers) are well-defined, red, skin ulcers that are usually not painful or itchy. They are most commonly found on the upper lip.

Is eosinophilic granuloma complex in cats contagious?

EGC is not contagious to other cats. It is an inflammatory condition caused by an inappropriate response by the cat’s immune system to some type of allergen (fleas or mosquitos, pollen, plastics, or foods/proteins) though in some cases, the underlying trigger cannot be identified.