What is a topoisomerase 1 inhibitor?
What is a topoisomerase 1 inhibitor?
Topoisomerase I inhibitors are a new class of anticancer agents with a mechanism of action aimed at interrupting DNA replication in cancer cells, the result of which is cell death. Irinotecan (CPT-11), a semi-synthetic derivative of camptothecin, is approved in the United States for the treatment of colorectal cancer.
What are topoisomerase 2 inhibitors?
Topoisomerase II is an enzyme essential for DNA replication, chromosome condensation and chromosome segregation. Inhibitors of topoisomerase II are important drugs used in the therapy of many neoplasms including breast cancer, lung cancer, testicular cancer, lymphomas and sarcomas.
Which of the following is a topoisomerase inhibitor?
Topoisomerase inhibitors in current use in the United States include irinotecan and topotecan, inhibitors of topoisomerase I, and etoposide and teniposide, inhibitors of topoisomerase II. All four agents are semisynthetic analogues of natural toxins that were initially identified in plants.
What prevents topoisomerase?
Topoisomerase I poisons are more widely used than temozolomide and DTIC in the treatment of cancer. Topoisomerase I reduces the torsional strain in DNA resulting from local unwinding for replication and transcription by forming a transient complex with DNA catalysing the cleavage, unwinding and relegation of DNA.
Is gemcitabine a topoisomerase inhibitor?
Gemcitabine (2′,2′-difluoro-2′-deoxycytidine), an antimetabolite that poisons topoisomerase I.
How does doxorubicin inhibit topoisomerase?
Doxorubicin inhibits topoisomerase II, which overwinds DNA during transcription, thereby preventing the recombination of the DNA double strand, thus stopping DNA replication2. Therefore, most of the research conducted on doxorubicin has been focused on the elimination of the anti-therapeutic effects.
Is etoposide topoisomerase inhibitor?
Etoposide was the first agent recognised as a topoisomerase II inhibiting anticancer drug. Research on etoposide has helped the understanding of mechanisms by which drugs poison topoisomerase II.
What are examples of quinolones?
Other quinolones
- Avelox (moxifloxacin)
- Cipro IV (ciprofloxacin)
- Cipro XR (ciprofloxacin)
- Penetrex (enoxacin)
- Factive (gemifloxacin)
- Maxaquin (lomefloxacin)
- Proquin XR (ciprofloxacin)
- Trovan (trovafloxacin)
Which drugs are metabolized by CYP2D6?
Overview. The impact of CYP2D6 activity in drug metabolism is further complicated by the activity of the drug itself on CYP2D6. Some SSRIs, such as paroxetine (Paxil), fluoxetine (Prozac), and citalopram (Celexa), as well as statins, are known to inhibit CYP2D6 activity and may make EMs resemble IMs or PMs.
How do topoisomerase inhibitors in chemotherapy work?
Topoisomerase inhibitors are chemotherapeutic agents that interfere with the topoisomerase enzymes (topoisomerase I and II), which control changes in DNA structure. Topoisomerase inhibitors block the ligation step of the cell cycle, which generates DNA single- and double-strand breaks, leading to apoptotic cell death.
Is propranolol a MAOI inhibitor?
Inderal is not a MAO inhibitor. It belongs to a class of drugs known as beta blockers. The information given above is for Propranolol which is the active ingredient of Inderal.
Is albuterol a MAOI inhibitor?
Monoamine Oxidase Inhibitors (MAOIs) Albuterol inhalers should be used with extreme caution in combination with MAOIs. Dangerously low blood pressure (hypotension) may occur as a result. Talk to your healthcare provider before combining albuterol inhaler with an MAOI.
