What is the use of hirudin?
What is the use of hirudin?
The anticoagulant hirudin, which is extracted from the body tissues of the European medicinal leech (Hirudo medicinalis), is used to prevent blood clots following surgery; another chemical isolated from Amazonian leeches is used to dissolve existing blood clots.
Which organism produces the anticoagulant hirudin?
Hirudin is a potent thrombin inhibitor originally derived from the medicinal leech, Hirudo medicinalis. Owing to its high affinity and specificity for thrombin, hirudin has been intensively investigated for research and therapeutic purposes.
What is the anticoagulant in leeches?
Leeches produce an enzyme in their saliva called hirudin. Hirudin is a powerful anticoagulant. They produce this to prevent their host from forming a clot so that they can feast on blood more easily.
What is the difference between hirudin and heparin?
The flexible negatively charged C-terminal tail of hirudin (amino acids 48–64) binds to the thrombin exosite I. Compared with the heparin-antithrombin III mechanism, hirudin has a greater ability to inhibit thrombin bound to fibrin. In contrast, heparin-AT has a relatively weak ability to inhibit clot-bound thrombin.
Is hirudin used in medicine?
Given the potent antithrombotic property, hirudin has been used to treat acute coronary artery disease, deep vein thrombosis and other thrombotic diseases (Zoldhelyi et al., 1993; Levin and Bergqvist, 2001).
How is hirudin produced?
One example of the value of traditional knowledge is the development of the recombinant pharmaceutical protein hirudin, a potent anticoagulant derived from the saliva of leeches (Hirudo medicinalis).
Is hirudin an anticoagulant?
Hirudin exemplifies antithrombin anticoagulants. It is a peptide of 65 amino acids with three disulfide bonds and is derived from the saliva of the medicinal leech. Hirudin forms a biomolecular complex with thrombin via its acidic C-terminus and thereby prevents the activity of thrombin.
What is recombinant hirudin?
Recombinant Hirudin is a potent thrombin inhibitor originally derived from the medicinal leech. Hirudin acts directly on thrombin rather than through other clotting factors. The mechanism of Hirudin-thrombin appears to be unique.
Is hirudin a natural anticoagulant?
Hirudin is a naturally occurring peptide in the salivary glands of blood-sucking leeches (such as Hirudo medicinalis) that has a blood anticoagulant property….
| Hirudin | |
|---|---|
| InterPro | IPR000429 |
| SCOP2 | 4htc / SCOPe / SUPFAM |
| showAvailable protein structures: |
What is hirudin how do you get it?
Hirudin is a polypeptide found in the salivary glands of the leech Hirudo medicinalis, and it is among the most potent of the natural thrombin inhibitors.
Which anticoagulant protein can be obtained from transgenic Brassica napus?
An anticoagulant protein that can be obtained from transgenicBrassica napus Hirudin is a protein that prevents blood clotting. Its gene was chemically synthesized and was transferred into Brassica napuswhere hirudin accumulates in seeds. The hirudin is extracted and purified and then used as medicine.
How were The RefSeq genome records annotated for Brassica napus?
The RefSeq genome records for Brassica napus were annotated by the NCBI Eukaryotic Genome Annotation Pipeline, an automated pipeline that annotates genes, transcripts and proteins on draft and finished genome assemblies.
What is Rutabega (Brassica napus)?
Brassica napus, or Rutabega, is an herbacious biennial grown primarily as a large annual root vegetable for its edible root and greens. It is believed to be a hybrid of a turnip ( Brassica rapa) and a cabbage ( Brassica oleracea) and is native to Scandinavia and Russia.
What is the difference between Brassica napus and Brassica rapa?
Brassica napus is a self-compatible species displaying a high degree of self-pollination, while most B. rapa is self-incompatible (except for the Indian subspecies yellow sarson, which is self-compatible) (Downey and Röbbelen, 1989).
