How does nesiritide help with heart failure?

How does nesiritide help with heart failure?

Nesiritide, a recombinant human B-type natriuretic peptide, is the first in a new drug class for the treatment of decompensated heart failure. The drug binds to receptors in the vasculature, kidney, adrenal gland, and brain, and overcomes resistance to endogenous BNP present in patients with CHF.

Is nesiritide used in congestive heart failure?

Nesiritide (Natrecor) is a recombinant form of human B-type (brain) natriuretic peptide that has beneficial vasodilatory, natriuretic, diuretic and neurohormonal effects. The drug is administered intravenously for the management of patients with decompensated congestive heart failure (CHF).

Is nesiritide discontinued?

On February 5, 2018, the Food and Drug Administration reported that Janssen Pharmaceuticals was discontinuing the manufacture of nesiritide, the recombinant human B-type natriuretic peptide.

What is a nesiritide infusion?

Natrecor (nesiritide) is indicated for the intravenous treatment of patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity. In this population, the use of Natrecor reduced pulmonary capillary wedge pressure and improved dyspnea.

Does nesiritide increase cardiac output?

Nesiritide may promote diuresis because of a direct natriuretic action, increased cardiac output, and/or decreased aldosterone levels. In patients hospitalized for decompensated HF, nesiritide improves symptoms and is well tolerated.

How is nesiritide administered?

NATRECOR (nesiritide) is for intravenous (IV) use only. There is limited experience with administering NATRECOR for longer than 96 hours. Monitor blood pressure closely during NATRECOR administration.

Does nesiritide increase heart rate?

The complete efficacy profile of nesiritide included preload reduction (PCWP and RAP), reductions in pulmonary artery pressures, afterload reduction (systemic vascular resistance), and increases in cardiac index and stroke volume index (which are dose-dependent and not the result of a direct inotropic effect), without …

How long can a patient stay on Natrecor infusion?

Natrecor is given as an infusion into a vein. A healthcare provider will give you this injection. This medicine must be given slowly, and the infusion may be given continuously for up to 96 hours. Your blood pressure and other vital signs will be watched closely.

How long can a patient stay on Natrecor?

NATRECOR (nesiritide) is for intravenous (IV) use only. There is limited experience with administering NATRECOR for longer than 96 hours.

Does Natrecor increase cardiac output?

Nesiritide does not affect the heart rate, but does increase the stroke volume and consequently cardiac output, resulting in a decrease in the symptoms of decompensated heart failure.