What are causes of pancytopenia?

What are causes of pancytopenia?

Some possible causes of pancytopenia include:

• Cancer.
• Lupus.
• Bone marrow disorders.
• Infections.
• Side effects of medicine.
• Exposure to toxins such as radiation, arsenic, or benzine.
• Chemotherapy treatments.
• Radiation treatments.

Why there is pancytopenia in megaloblastic anemia?

The causes of pancytopenia are bone marrow-originated causes (aplastic anemia, myelodysplastic syndrome, etc), bone marrow infiltration (myelofibrosis, acute leukemia, multiple myeloma, metastatic carcinoma, hairy cellleukemia), splenomegaly (congestive splenomegaly, hematological malignancies splenic infiltration.

What is pancytopenia and what does it mean?

A condition in which there is a lower-than-normal number of red and white blood cells and platelets in the blood. Pancytopenia occurs when there is a problem with the blood-forming stem cells in the bone marrow.

What is Trilineage dysplasia?

Acute myeloid leukaemia (AML) with trilineage dysplasia (AML/TLD) is de novo AML recognized by the morphological dysplasia of three mature cell lines in the presence of leukaemic blasts.

Why does leukemia cause pancytopenia?

Pancytopenia can result from aplastic anemia (reduction in hematopoietic stem cell production) or it may arise from infection, infiltration of bone marrow, immune-mediated damage or hypersplenism in which normal cells trapped in hypertrophied and overactive reticuloendothelial system (1, 6).

How does leukemia cause pancytopenia?

Acute promyelocytic leukemia is particularly prone to presenting with leukopenia as opposed to high white counts and can quickly turn to a medical emergency due to the coagulopathy it can cause. High-grade lymphomas and plasma cell myeloma also commonly replace the bone marrow and can cause pancytopenia.

What is pancytopenia Anaemia?

Pancytopenia is a descriptive term referring to the combination of low levels of all of the types of blood cells including red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia).

What is myelodysplasia with multilineage dysplasia?

Myelodysplastic syndrome (MDS) with multilineage dysplasia (MDS-MLD), is an MDS characterized by one or more cytopenias and dysplastic changes in two or more of the myeloid lineage (erythroid, granulocytic, and megakaryocytic).

What is the difference between neutropenia and pancytopenia?

Neutropenia is diagnosed from a blood test called complete blood count (CBC) with differential. Importantly, the CBC with differential will also reveal if other cell lines are low. Pancytopenia is diagnosed when white blood cell, red blood cell, and platelet counts are low.

What is central pancytopenia?

Pancytopenia is a condition in which a person’s body has too few red blood cells, white blood cells, and platelets.

What happens in pancytopenia?

Pancytopenia occurs when a person has a decrease in all three blood cell types. This happens when something is wrong with the bone marrow, where blood cells are formed. Pancytopenia has many possible causes: Diseases such as cancer, lupus or bone marrow disorders.