Are C57BL 6 mice genetically identical?
Are C57BL 6 mice genetically identical?
Our C57BL/6 mouse colonies are genetically identical within each strain, making them free of genetic differences that could impact research results.
How many MHC haplotypes are there?
Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.
Why use C57BL 6 mice?
C57BL/6 mice is an inbred mouse strain originally developed for the study of antitumor activity and immunology, and is increasingly being used as an basic background strain. It is known that cell-mediated immunity and NK cell activity are of relatively high importance in determining immunological characteristics.
What is the difference between C57BL 6N and C57BL 6J?
C57BL/6J mice express a mutant Nnt gene, which is involved in glucose-mediated insulin secretion, compared to C57BL/6N substrains (Freeman et , 2006). C57BL/6N substrains harbor the retinal degeneration allele Crbrd8 while the C57BL/6J substrain carries a wildtype allele (Mattapallil et al., 2012).
How many distinct MHC haplotypes does the genome of an individual person contain?
And as the codominant expression character (both the maternal and paternal inherited MHC genes are expressed) of MHC gene products, every person expresses at least six different MHC class I molecules and eight different MHC class II molecules on his or her cells.
Is C57BL 6 mice wild type?
C57BL/6 mice are widely used in biomedical research for the background of genetically engineered mice (GEM) and wild-type controls with the belief that the genetic background of GEM and control mice differ significantly by only one or more altered gene.
How are haplotypes generated?
A haplotype (haploid genotype) is a group of alleles in an organism that are inherited together from a single parent. Many organisms contain genetic material (DNA) which is inherited from two parents. Normally these organisms have their DNA organized in two sets of pairwise similar chromosomes.
