Can oxacillin treat staphylococcus aureus?

Can oxacillin treat staphylococcus aureus?

When resistance was first described in 1961, methicillin was used to test and treat infections caused by S. aureus. However, oxacillin, which is in the same class of drugs as methicillin, was chosen as the agent of choice for testing staphylococci in the early 1990s.

What antibiotics is Staphylococcus sensitive to?

The overall percentages of S. aureus sensitive to the tested antibiotics were as follows: methicillin 85%, penicillin 8%, gentamicin 89%, ciprofloxacin 85%, erythromycin 80%, fusidic acid 96%, mupirocin 98%.

Why is Staphylococcus aureus sensitive to antibiotics?

The resistance of S. aureus to methicillin is due to the production of penicillin-binding protein 2a (PBP2a), which is encoded by the mecA gene located on the mobile gene element (MGE) of the staphylococcal chromosome cassette mec (SCCmec), which has a low affinity for beta-lactam antibiotics [25,26].

What type of bacteria does oxacillin treat?

What is oxacillin? Oxacillin is a penicillin antibiotic that fights bacteria in the body. Oxacillin is used to treat many different types of infections caused by staphylococcus (also called “staph” infection).

Is methicillin and oxacillin the same?

Oxacillin is a penicillinase-resistant β-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Other related compounds are nafcillin, cloxacillin, dicloxacillin, and flucloxacillin.

What is the difference between oxacillin and methicillin?

Oxacillin is more stable than methicillin and is a better predictor, at least in MIC tests, of strains of staphylococci that carry the mecA methicillin resistance gene. Even so, detection of oxacillin resistance in staphylococci can be difficult because oxacillin-resistant strains, particularly of S.

Is Staphylococcus aureus susceptible to penicillin?

aureus do not produce a beta-lactamase and remain susceptible to penicillin G. beta-lactamase-mediated resistance results from production of an enzyme that is excreted extracellularly by S. aureus that inactivates the antibiotic by opening the beta-lactam ring.

What is the best drug to treat staphylococcus?

Vancomycin increasingly is required to treat serious staph infections because so many strains of staph bacteria have become resistant to other traditional medicines. But vancomycin and some other antibiotics have to be given intravenously.

Is Staph aureus sensitive to amoxicillin?

Drugs such as amoxicillin and ampicillin are beta-lactamase susceptible and should not be relied upon to treat lower extremity Staph infections. Patients will often begin self-treatment with these agents as they may have a few capsules left over from an ear or dental infection.

Is oxacillin a broad spectrum antibiotic?

Oxacillin has a limited spectrum of activity that includes primarily gram-positive bacteria. Resistance is common, especially among enteric gram-negative bacilli. Staphylococci are susceptible because oxacillin is resistant to the bacterial beta-lactamase produced by Staphylococcus spp.