What effect does Pirenzepine produce?
What effect does Pirenzepine produce?
Pirenzepine is well tolerated by most patients, with a low incidence of typical antimuscarinic effects on the gastrointestinal tract, genitourinary system or heart being reported in clinical studies. However, dry mouth and blurred vision are the more common side effects with clinically effective doses.
How does pirenzepine work?
Pirenzepine is a muscarinic receptor antagonist and binds to the muscarinic acetylcholine receptor. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
Is pirenzepine selective?
Pirenzepine is an anticholinergic drug with selective effects on muscarinic M1 receptors, although there is also evidence that it can be an antagonist at M2 receptors as well.
Is Pirenzepine a H2 receptor antagonist?
Abstract. 1 The H2-receptor antagonists, ranitidine and cimetidine, have been compared with atropine and pirenzepine for their effects on gastric acid output, and on salivary secretion from the left parotid gland in the anaesthetized dog.
Why Pirenzepine is used for treating ulcers?
Pirenzepine (Gastrozepin), an M1 selective antagonist, is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm.
How do you take Pirenzepine?
The dose is usually 50mg up to three times daily. The maximum dose is 150mg (three tablets) in a day. How should pirenzepine be taken? Pirenzepine is usually taken two to three times a day.
Why Pirenzepine is used for treating ulcer?
What is the mechanism of pirenzepine gel in controlling myopia?
It has been shown to prevent the development of form-deprivation myopia in chicks,3 tree shrews,4 and rhesus monkeys. In chicks, pirenzepine prevents form-deprivation myopia through a nonaccommodative mechanism,6 by preventing axial elongation through transient modulation of scleral glycosaminoglycan synthesis.
Is tolterodine bad for your kidneys?
Tolterodine may worsen this condition. Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects.
