What is platelet Desialylation?
What is platelet Desialylation?
A new and original concept relates to platelet desialylation a process in which terminal sialic acids are cleaved on the platelet surface and leads to accelerate platelet clearance and thrombocytopenia. Sialic acids are terminal sugar components of glycoprotein oligosaccharide chains.
Is low platelets an emergency?
A platelet count less than 5 × 103 per μL may cause spontaneous bleeding and constitutes a hematologic emergency. Patients who present with thrombocytopenia as part of a multisystem disorder usually are ill and require urgent evaluation and treatment.
Can you work with low platelet count?
If your blood platelet count or other medical tests don’t quite meet the criteria outlined for Social Security Disability, you may still qualify if you are able to prove that you are incapable of performing any meaningful work.
Can low platelets cause infection?
Low platelet count is correlated with increased risk of infection. As shown in Fig. 1, lower platelet counts led to more infections.
What autoimmune diseases cause low platelets?
Autoimmune diseases, such as lupus and rheumatoid arthritis, cause this type. The body’s immune system mistakenly attacks and destroys platelets. If the exact cause of this condition isn’t known, it’s called idiopathic thrombocytopenic purpura.
What does it mean when your platelet count is low?
Thrombocytopenia (low platelet count) Print. Thrombocytopenia is a condition in which you have a low blood platelet count. Platelets (thrombocytes) are colorless blood cells that help blood clot. Platelets stop bleeding by clumping and forming plugs in blood vessel injuries.
Do Kupffer cells play a role in the clearance of desialylated platelets?
The liver also contains an abundance of a professional type of phagocytes known as Kupffer cells, which comprises the largest population of resident tissue macrophages in the body [ 17, 18 ]. Our recent study supports Kupffer cells, instead of hepatocytes, in playing the major role in clearance of desialylated platelets [ 9 ].
What causes enlarged spleen and low platelets?
Enlarged spleen. Thrombocytopenia can be inherited or it may be caused by a number of medications or conditions. Whatever the cause, circulating platelets are reduced by one or more of the following processes: trapping of platelets in the spleen, decreased platelet production or increased destruction of platelets.
What causes platelets to stop bleeding in adults?
Overview. Platelets stop bleeding by clumping and forming plugs in blood vessel injuries. Thrombocytopenia often occurs as a result of a separate disorder, such as leukemia or an immune system problem. Or it can be a side effect of taking certain medications. It affects both children and adults.
