How common is HLA-A2?
How common is HLA-A2?
References (1) HLA-A2 is the most frequent HLA-A type in all ethnic groups (22). HLA-A2 is also expressed in about 40% of Japanese persons (23,24) and in about 50% of Caucasians (25) .
What type of HLA is most prevalent?
Results: We found that, for class I, HLA-A*02,HLA-B*35, and HLA-A*24 and, for class II, DRB*11, DRB*01, and DRB*04 were the 4 most common antigens and HLAA02, B49, A68, B7 were the 3 most common anti-HLA antibodies, with mean fluorescence intensity values ≥ 2000 in our population group.
What does HLA-A2 code for?
HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus….HLA-A*02.
| HLA-A2 | |
|---|---|
| Older names | HL-A2 |
| Subtypes |
What percentage of the population has HLA?
Evaluation and Differential Diagnosis of Polyarthritis The HLA-B27 gene marker is found in approximately 3% to 8% of the population, but it is found in more than 90% of patients with ankylosing spondylitis and in 50% to 80% of patients with other SpAs.
What percentage of people with HLA-B27 have as?
Results: The age-adjusted US prevalence of B27 was 6.1% (95% confidence interval [95% CI] 4.6-8.2). By race/ethnicity, the prevalence of B27 was 7.5% (95% CI 5.3-10.4) among non-Hispanic whites and 3.5% (95% CI 2.5-4.8) among all other US races/ethnicities combined.
What is the most frequently detected HLA-A2 allele?
Predominance Of A*02011 and identification of HLA-A*0231 Direct DNA sequencing was used to determine the frequency of alleles within the HLA-A2 family in five US population groups. The most frequently detected HLA-A2 allele in all groups was HLA-A*02011.
How many types of HLA-A*02 are there?
The A*02 allele group can code for many proteins; as of December 2013 there are 456 different HLA-A*02 proteins. Serotyping can identify as far as HLA-A*02, which is typically enough to prevent transplant rejection (the original motivation for HLA identification). Genes can further be separated by genetic sequencing and analysis.
Does HLA-A2 contribute to the risk of Alzheimer’s disease?
This study provided preliminary evidences supporting HLA-A2 in Caucasians contribute to the risk of Alzheimer’s disease. HLA-A*33:01 was associated with drug induced liver injury due to terbinafine and possibly fenofibrate and ticlopidine.
How common is HLA A02 in Hodgkin lymphoma?
HLA-A*02 has been linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma (HL). Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group.
