Which antibiotics are contraindicated in Long QT Syndrome?
Which antibiotics are contraindicated in Long QT Syndrome?
Table 1
| Drugs to be avoided in patients with c-long QT syndrome | |
|---|---|
| Antibiotic | Moxifloxacin, Clarithromycin, Ciprofloxacin, Gemifloxacin, Ofloxacin Telithromycin, Levofloxacin, Roxithromycin, Trimethoprim-Sulfa, Gatifloxacin, Sparfloxacin, Azithromycin Erythromycin |
What drug is recommended to treat patients with drug induced QT prolongation?
Antiarrhythmic agents such as quinidine and disopyramide are known to block both the sodium and potassium channels, and are associated with QT interval prolongation. TdP was reported with these drugs at therapeutic or subtherapeutic doses.
Does doxycycline prolong QT interval?
Of the macrolides, azithromycin,17, 18 clarithromycin,19, 20 erythromycin21, 22 and roxithromycin23 have all been shown to prolong the QT interval. Doxycycline, a tetracycline antibiotic, should be considered to replace azithromycin or roxithromycin for treatment of atypical pneumonia.
Does levofloxacin prolong QT interval?
The cardiac toxicity issue at the center of this discussion is the prolongation of the QT interval leading to torsade de pointes. Ciprofloxacin and levofloxacin, two of the more commonly used fluoroquinolones, are considered less likely than other fluoroquinolones to prolong the QT interval.
Does metoprolol increase QTc?
Conclusions/interpretation: This study is the first to address the QTc interval and QTc dispersion in Type 1 diabetic patients treated with metoprolol. Beta blocker treatment caused a decrease in QTc interval but no change in QTc dispersion.
How can we improve treatment for long QT syndrome?
A combination of advances in the field of genetics, computerized clinical decision support systems that alert doctors to drug interactions, and handheld or wearable monitors may help improve treatment for people with both inherited and acquired long QT syndrome.
Are antibiotics linked to QT prolongation?
Antibiotics that have been implicated in acquired QT prolongation as well as clinically important torsades de pointes are listed on websites dedicated to the dissemination of this information to patients and providers (Tables 1-3).
Should concomitant use of two QT prolonging drugs be avoided?
Despite this lack of clinical data, warnings to avoid the concomitant use of two QT prolonging drugs appear in US drug labels.
Which beta blockers are used to treat long QT syndrome?
Beta blockers used to treat long QT syndrome include nadolol (Corgard) and propranolol (Inderal LA, InnoPran XL).
