What is aldol reaction with example?
What is aldol reaction with example?
Aldol structural units are found in many important molecules, whether naturally occurring or synthetic. For example, the aldol reaction has been used in the large-scale production of the commodity chemical pentaerythritol and the synthesis of the heart disease drug Lipitor (atorvastatin, calcium salt).
What type of reaction is an aldol reaction?
An aldol condensation is a condensation reaction in organic chemistry in which an enol or an enolate ion reacts with a carbonyl compound to form a β-hydroxyaldehyde or β-hydroxyketone (an aldol reaction), followed by dehydration to give a conjugated enone.
What is a crossed aldol reaction?
An aldol reaction between two different carbonyl compounds is called a crossed aldol or mixed aldol reaction. For example, if we mix acetaldehyde and propanal in presence of sodium hydroxide, a crossed aldol reaction is expected to occur with four different products.
What is alpha hydrogen?
An alpha (symbol: α) hydrogen is a hydrogen atom on an alpha carbon in an organic molecule; a hydrogen atom on a beta carbon is a beta hydrogen, and so on (α, ß, γ, δ…).
What is ENOL and Enolate?
Enols can be viewed a alkenes with a strong electron donating substituent. Enolates are the conjugate bases or anions of enols (like alkoxides are the anions of alcohols) and can be prepared using a base.
What is an aldol group?
In organic chemistry, an aldol describes a structural motif consisting of a 3-hydroxy ketone or 3-hydroxyaldehyde. Aldols are usually the product of aldol addition.
How many crosses does aldol have?
FOUR PRODUCTS ARE OBSERVED WHEN A CROSSED ALDOL IS ATTEMPTED USING TWO DIFFERENCE CARBONYL COMPOUNDS BOTH OF WHICH HAVE ALPHA H. q Note that there are two different enolates, that of acetaldehyde and that of propanal. Also, there are two different carbonyl compounds, ethanal and propanal.
Why aldehyde is excellent reagent for cross aldol?
First, aldehydes are more reactive acceptor electrophiles than ketones, and formaldehyde is more reactive than other aldehydes. Second, aldehydes lacking alpha-hydrogens can only function as acceptor reactants, and this reduces the number of possible products by half.
What is the product of an aldol addition?
The aldol addition in a nutshell is when the newly formed enolate reacts with another aldehyde or ketone to form a new carbon-carbon bond and thus a larger organic compound. Kind of like building railroad tracks! The general form of the aldol addition is enolate + aldehyde or ketone = aldol product.
https://www.youtube.com/watch?v=PzLgmB6WJrY
