What are the site specific drug delivery systems?
What are the site specific drug delivery systems?
Site specific drug delivery refers to targeting a drug directly to a certain biological location. Targeted drug delivery implies selective and effective localization of drug into the target at therapeutic concentrations with limited access to non target sites.
What is a prodrug explain with example?
Prodrug: A precursor (forerunner) of a drug. A prodrug must undergo chemical conversion by metabolic processes before becoming an active pharmacological agent. For example, sulfasalazine is a prodrug. It is not active in its ingested form.
What are prodrugs and its applications?
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted (ADME).
What is a prodrug in pharmacology?
A prodrug can be defined as a drug substance that is inactive in the intended pharmacological actions and is must to be converted into the pharmacologically active agent by metabolic or physico-chemical transformation.
What is site specific targeting?
The SST plan is OSHA’s main site-specific programmed inspection initiative for non- construction workplaces that have 20 or more employees. The SST program uses objective data from injury and illness information that employers submit under 29 CFR ยง 1904.41.
Which of the following will be a pharmaceutical application of prodrugs?
Which of the following will be the pharmacokinetic application of prodrugs? Pharmacokinetic applications are such as enhancement of bioavailability, prevention of presystemic metabolism, prolongation of the duration of action, reduction of toxicity, etc.
What is a prodrug and its difference from a drug?
A drug is a medication that is already pharmacologically active when administered: it is the form that most drugs come in. A prodrug is a medication that the body converts into a pharmacologically active drug after it is administered.
How prodrugs are used for enhancing the bioavailability of drugs?
Prodrugs are an alternative way to increase the aqueous solubility of the parent drug molecule by improving dissolution rate via attached ionizable or polar neutral functions, such as phosphates, amino acids, or sugar moieties [2, 5, 10,12].
What is the difference between drug and prodrug?
Drugs can be metabolized by several tissues and organs, such as the kidneys, lungs and intestines, but the main site of metabolism is the liver, which is rich in enzymes. A prodrug is a medication that the body converts into a pharmacologically active drug after it is administered.
What is the pharmacokinetics application of prodrug?
The prodrug design is a versatile, powerful method that can be applied to a wide range of parent drug molecules, administration routes, and formulations. Clinically, the majority of prodrugs are used with the aim of enhancing drug permeation by increasing lipophilicity, or by improving aqueous solubility.
What are the types of prodrugs?
There are two major types of prodrugs. These categories are based on how prodrugs are converted in the body: 1) Type I prodrugs turn into their active forms inside of cells. 2) Type II prodrugs turn into their active forms outside of cells, such as in blood or other fluids.
What are the advantages of prodrugs?
Prodrugs can improve how an active drug molecule is absorbed, distributed, metabolized and eliminated. Designed to maximize the amount of active drug that reaches its site of action, prodrugs contain a carrier that will be removed by either enzymatic cleavage or chemical reaction.
