Can thrombocytosis affect pregnancy?

Can thrombocytosis affect pregnancy?

Treatment of patients with essential thrombocytosis during pregnancy is challenging and young women are reported to be at increased risk of first trimester abortions and other pregnancy complications.

Can a person with thrombocytosis take aspirin?

Once-daily aspirin 75 to 100 mg is the current recommended antithrombotic regimen for patients with essential thrombocythemia (ET), but once-daily aspirin may not be enough to consistently inhibit platelet cyclooxygenase (COX)-1.

When do you give aspirin for thrombocytosis?

In general, no treatment is indicated to directly reduce the platelet count. However, for patients with platelet counts in excess of 1,000,000/μL, aspirin 65 mg daily may be considered to minimize the rare development of stroke or thrombosis.

How is ET treated in pregnancy?

Aspirin: We propose that all patients with ET or PV should be treated with low- dose aspirin (50 to 100 mg/day) throughout pregnancy and for six weeks post- partum. Of course, aspirin is contraindicated, if there is a significant bleeding diathesis or in patients with a peptic ulcer disease.

What causes reactive thrombocytosis?

[5] Reactive causes of thrombocytosis include transient processes such as acute blood loss, acute infection, or sustained forms of reactive thrombocytosis include iron deficiency, asplenia, cancer, chronic inflammatory, or infectious diseases.

Should I worry about a slightly elevated platelet count?

Potential Complications It is possible, however, that having high platelet counts can lead to the development of blood clots. If you have elevated platelets and are concerned about the risk of developing blood clots, talk to your healthcare providers about ways to reduce the risk of blood clots.

How do you treat reactive thrombocytosis?

Reactive thrombocytosis is usually managed by treating the underlying condition. For instance, if the reactive thrombocytosis is caused by anemia, once the anaemia is treated, the platelet count may return to normal. Medications to treat high platelet count include hydroxyurea, anagrelide and interferon alfa.

When should I worry about high platelet count in pregnancy?

As elevated platelet counts can be an indicator of an underlying medical condition, it is highly recommended that you further consult and discuss with your doctor to address your concerns, especially if your high platelets condition is persistent.

How do you deal with thrombocytosis?

Your doctor might prescribe platelet-lowering drugs primarily in the form of hydroxyurea (Droxia, Hydrea) or interferon alfa (Intron A). Platelets can be removed from your blood by a procedure that’s similar to dialysis.

Can birth control cause elevated platelets?

Certain drugs including birth control pills and estrogen cause higher platelet count. Due to genetic defects, inherited disorders like Glanzmann’s Thrombasthenia, Chediak-Higashi syndrome, May-Hegglin syndrome and Down syndrome etc. cause higher platelet counts.

What infections cause reactive thrombocytosis?

The most common infectious causes of thrombocytosis were soft-tissue, pulmonary and GI infections.

What is the prognosis of pregnancy-related thrombocytosis?

[Pregnancy-related thrombocytosis] Pregnancy-related thrombocythaemia comprises myeloproliferative and inflammatory reactive subsets. In pregnant women treated for myeloproliferative disorders, especially polycythaemia vera and primary thrombocytosis, only 50-70 per cent are delivered successfully of a normal healthy baby.

Is aspirin or interferon-a better for platelet control during pregnancy?

The addition of low dose aspirin seems to be beneficial in most cases improving pregnancy outcome whereas interferon-a is the cytoreductive drug of choice when platelet control is needed during pregnancy.

Does aspirin cause thrombosis in platelets?

In either setting, aspirin is widely used in clinical practice. However, RT (even at platelet counts >1000 x 109/l) has never been shown to cause thrombosis or bleeding due to acquired von Willebrand factor defects in association with high platelet counts.

Are You at risk for primary or secondary thrombocytosis?

Primary thrombocythemia is more common in people aged 50 to 70, but it can occur at any age. For unknown reasons, more women around the age of 30 have primary thrombocythemia than men of the same age. You might be at risk for secondary thrombocytosis if you have a disease, condition, or factor that can cause it.