Where is CD62L expressed?
Where is CD62L expressed?
CD62L is expressed by murine ILCs. (A) Gating of the different subsets of ILCs in mouse lymphoid organs.
What does CD62L stand for?
L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes and the preimplantation embryo. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups.
What is CD69 a marker for?
The expression of CD69 in infiltrating lymphocytes in inflamed tissues is a marker of different signaling pathways, which potentially regulate tissue retention, metabolism and their activated phenotype.
Do NK cells express CD62L?
Thus, while CD56bright NK cells are mostly CD62L+, KIR−, NKG2A+, and CD27dim, the majority of CD56dim NK cells are CD62L−, KIR+, NKG2A−, and CD27− (Figure 4A).
What are CD45RA cells?
CD45RA T cells have “naive” characteristics of unresponsiveness to recall antigens and prominence in cord blood, while CD45RO T cells are considered “memory” T cells because they proliferate to recall antigens and increase following PHA activation of cord blood.
What is CD27 a marker for?
CD27+ B cells are larger cells with abundant cytoplasm carrying somatic hypermutation, and have an ability to produce immunoglobulin, indicating that CD27 is a memory marker of B cells. The ligation of CD27 yields crucial signals that positively control the entry of B cells into the pathway to plasma cells.
What is CD69 in immunology?
CD69 (Cluster of Differentiation 69) is a human transmembrane C-Type lectin protein encoded by the CD69 gene. It is an early activation marker that is expressed in hematopoietic stem cells, T cells, and many other cell types in the immune system.
How is CD69 regulated?
CD69 is up-regulated by thymocyte-positive selection, and different TCR Tg mouse strains express characteristic quantities of CD69 based on both the selecting background and the strength of TCR-MHC/peptide interactions (30).
What are TSCM cells?
In Brief. Stem cell-like memory T (TSCM) cells are multipotent progenitors that can both self-renew and replenish more differentiated subsets of memory T cells. Ahmed et al.
What is Temra cell?
However, a subset of effector memory T cells re-expresses CD45RA (termed TEMRA) after antigenic stimulation with unknown molecular characteristics and functions. CD4 TEMRA cells have been implicated in protective immunity against pathogens such as dengue virus (DENV).
Which type of B cell expresses CD27?
human memory B cells
7 Others. CD27, a member of the TNF-receptor superfamily, is expressed on human memory B cells and highly expressed on the surface of human but not on murine plasma cells (Jung, Choe, Li, & Choi, 2000).
Do B cells have CD69?
CD69 is a type II C-type lectin involved in lymphocyte migration and cytokine secretion. We concluded CNS1-4 are important cis-regulatory elements that interact both positively and negatively with the CD69 promoter and that differentially contribute to CD69 expression in T and B cells.
