What is the action of dipyridamole?

What is the action of dipyridamole?

Dipyridamole appears to act in vivo by synergistically modifying several biochemical pathways, including: a) inhibition of platelet cAMP-phosphodiesterase; b) potentiation of adenosine inhibition of platelet function by blocking reuptake by vascular and blood cells, and subsequent degradation of adenosine; and possibly …

What is the mechanism of action of drugs?

In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor.

What drugs cause Tachyphylaxis?

Over-the-counter ophthalmic decongestant drops, such as Visine (Pfizer), are another category of drugs that induce tachyphylaxis. In particular, these medications contain alpha-adrenergic amines—such as tetrahydrozoline, naphazoline or phenylephrine—that act as vasoconstrictors.

What is the mechanism of action for aripiprazole?

Aripiprazole functions as a partial agonist at the dopamine D2 and the serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptor. The mechanism of action of aripiprazole, as with other drugs having efficacy in schizophrenia and bipolar disorder, is unknown.

Is dipyridamole phosphodiesterase inhibitor?

Dipyridamole is a pyramidopyrimidine compound that, acting as a phosphodiesterase inhibitor, modestly reduces platelet function. Dipyridamole also has important endothelial activity and acts as a vasodilator. Dipyridamole inhibits the attachment of platelets to the endothelium.

Why is dipyridamole contraindicated in angina?

Patients with active bronchospasm or patients being treated for reactive airway disease should not be administered dipyridamole because this can lead to prolonged bronchospasm, which can be difficult to treat or can remain refractory.

What are the 5 mechanisms of drug action?

Molecular– Receptor, ion channel, enzyme, carrier molecules. Cellular– Transduction e.g., G protein, ion channel, enzyme. Tissue– Contraction, secretion, metabolic activity, proliferation.

What does drug tachyphylaxis mean?

Tachyphylaxis is the loss of response of tissues following repeated or continuous administration of a drug.

Does nitroglycerin cause tachyphylaxis?

For example, since nitroglycerine demonstrates tachyphylaxis, you should wait for durations of time (i.e., drug-free intervals) between doses to allow patients to remain sensitive to the drug effects.

What receptors does aripiprazole work?

Aripiprazole is a partial agonist at D2 receptors. It may act as an antipsychotic by: Lowering dopaminergic neurotransmission in the mesolimbic pathway. Enhancing dopaminergic activity in the mesocortical pathway.

Does aripiprazole block dopamine?

To summarize, aripiprazole, as a dopamine partial agonist, acts as a modulator of dopamine effects. When present, it diminishes the effects of both dopamine excess (by decreasing dopamine action when there is too much of it) and deficit (by increasing dopamine action when there is too little of it).