What does indeterminate Western blot mean?

What does indeterminate Western blot mean?

An indeterminate Western blot result can result from true infection (eg, HIV-1 infection that has not completely seroconverted, advanced AIDS, HIV-2 infection) or no infection (eg, participant in a HIV-1 vaccine trial, pregnancy, elevated bilirubin levels, hemodialysis, malignancy, autoimmune diseases).

Why might an Elisa test be indeterminate?

An indeterminate result means that the test kit shows a weak positive reaction, perhaps because of an unknown antibody cross-reaction, because of cross-contamination with another person’s sample or because of another technical error.

Is the Western blot test more accurate than the Elisa test?

Currently licensed ELISA tests have greater than 98% sensitivity and specificity for HIV. Western blot analysis detects antibodies to specific HIV antigens and is best used as a confirmatory test. In spite of the high sensitivity and specificity of both tests, false-positive and false-negative results do occur.

What if Elisa test is negative?

If antibodies to HIV are present (positive), the test is usually repeated to confirm the diagnosis. If ELISA is negative, other tests usually aren’t needed. This test has a low chance of having a false result after the first few weeks that a person is infected. Polymerase chain reaction (PCR).

What is indeterminate abnormality?

A test sample for COVID-19 (coronavirus) may not always give a clear result. This is called an indeterminate, invalid or inhibitory result. It means that the test could not detect if you have COVID-19.

What does an indeterminate result mean to a patient?

Listen to pronunciation. (IN-deh-TER-mih-nut reh-ZULT) A negative test result in an individual where a clearly deleterious mutation has not been found in any family members.

What is an indeterminate result?

Can Western blot test be wrong?

Since the Western blot test checks for antibodies, it may give false negatives for both conditions if it’s administered too soon. In some instances, certain conditions such as lupus may also cause false positives to occur.

How accurate is the Western blot test?

The Western blot test separates the blood proteins and detects the specific proteins (called HIV antibodies) that indicate an HIV infection. The Western blot is used to confirm a positive ELISA, and the combined tests are 99.9% accurate.

How accurate is Elisa test?

Although false negative or false positive results are extremely rare, they may occur if the patient has not yet developed antibodies to HIV or if a mistake was made at the laboratory. When used in combination with the confirmatory Western blot test, ELISA tests are 99.9% accurate.

What does indeterminate mean on a mammogram?

Dr. Of those mammography results, a large percentage will be an indeterminate result where the person needs to come back for more views.

What does indeterminate significance mean?

open to two or more interpretations; or of uncertain nature or significance; or (often) intended to mislead. adjective. not leading to a definite ending or result. “an indeterminate campaign” Synonyms: inconclusive.