What is C-myc epitope?
What is C-myc epitope?
The Myc tag, derived from the c-Myc protein, is a popular epitope tag for detecting the expression of recombinant proteins in yeast, bacteria, insect, and mammalian cell systems. The Myc tag may be fused to either the N-terminus or C-terminus of a protein.
Is C-MYC an oncogene or tumor suppressor?
Although the Myc gene was originally identified as an oncogene, it is involved in various cellular processes, including cell growth, proliferation, loss of differentiation, and apoptosis (Adhikary and Eilers, 2005; Pelengaris et al., 2002; Thompson, 1998).
What chromosome is C-MYC on?
The results indicate that the human c-myc gene is located on chromosome 8. The analysis of hybrids between rodent cells and human Burkitt lymphoma cells, which carry a reciprocal translocation between chromosomes 8 and 14, allowed the mapping of the human c-myc gene on region (q24 leads to qter) of chromosome 8.
What is myc Code C?
In cancer, c-myc is often constitutively (persistently) expressed. This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of cancer….Myc.
| MYC proto-oncogene, bHLH transcription factor | |
|---|---|
| Identifiers | |
| NCBI gene | 4609 |
| HGNC | 7553 |
| OMIM | 190080 |
What is C-myc antibody?
The c-Myc protein is an oncogenic transcription factor, encoded by the c-Myc gene on human chromosome 8q24. The anti-c-Myc antibody recognizes an epitope located within the amino acid sequence (Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu-) of the product of the human oncogene c-myc, also known as the c-Myc tag.
What is myc for?
Is MYC a gene?
MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement.
Why MYC is a proto-oncogene?
The proto-oncogene, MYC, lies at the crossroads of many growth promoting signal transduction pathways and is an immediate early response gene downstream of many ligand-membrane receptor complexes (Armelin et al., 1984; Kelly et al., 1983) (Figure 1A).
What does the MYC gene do?
MYC gene encodes a multifunctional, nuclear phosphoprotein that controls a variety of cellular functions, including cell cycle, cell growth, apoptosis, cellular metabolism and biosynthesis, adhesion, and mitochondrial biogenesis.
Is MYC a Tumour suppressor gene?
C-MYC: Oncogene and Tumour Suppressor Gene.
What is c-myc promoter?
The transcription factor c-Myc is a key regulator of cell proliferation, cell growth, differentiation, and apoptosis. Deregulated c-myc expression possesses a high transformation potential and the proto-oncogene c-myc represents a promising target in anticancer therapy.
When was c-myc discovered?
Identification of MYC In the late 1970s, an avian acute leukemia virus (MC29) was shown to promote a spectrum of malignancies, including myelocytomas, sarcomas, and importantly, carcinomas. This ability to induce carcinomas was of particular interest because this represented the most common form of human malignancy.
What is the structure of the MYC family of genes?
Structure. The protein product of Myc family genes all belong to the Myc family of transcription factors, which contain bHLH (basic helix-loop-helix) and LZ ( leucine zipper) structural motifs. The bHLH motif, allows Myc proteins to bind with DNA, while the leucine zipper TF-binding motif allows dimerization with Max,…
What is the role of c-Myc in the pathogenesis of cancer?
In cancer, c-myc is often constitutively (persistently) expressed. This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of cancer. A common human translocation involving c-myc is critical to the development of most cases of Burkitt lymphoma.
What is the clinical significance of the MYC gene amplification?
Clinical significance. In TCGA datasets, the amplification of Myc occurs in several cancer types, including breast, colorectal, pancreatic, gastric, and uterine cancers. In the experimental transformation process of normal cells into cancer cells, the MYC gene can cooperate with the RAS gene.
What is the role of c-Myc in Burkitt lymphoma?
A common human translocation involving c-myc is critical to the development of most cases of Burkitt lymphoma. Constitutive upregulation of Myc genes have also been observed in carcinoma of the cervix, colon, breast, lung and stomach. Myc is thus viewed as a promising target for anti-cancer drugs.
