What is DOTATOC scan?

What is DOTATOC scan?

DOTATOC is a somatostatin analogue that localizes on the somatostatin receptors expressed by NETs and is attached to a radioactive material called Gallium 68. Participants will undergo a PET/CT imaging study to investigate 68Ga-DOTATOC’s suitability as a positron emission tomography (PET) imaging agent for NETs.

What is Ga 68 used for?

Gallium Ga 68 dotatate injection is used with a PET scan (positron emission tomography) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adults and children.

What is the difference between Dotatate and DOTATOC?

The 2 compounds most often used in functional imaging with PET are (68)Ga-DOTATATE and (68)Ga-DOTATOC. Both ligands share a quite similar sst binding profile. However, the in vitro affinity of (68)Ga-DOTATATE in binding the sst subtype 2 (sst2) is approximately 10-fold higher than that of (68)Ga-DOTATOC.

How long does a gallium 68 scan take?

The Gallium-68 PET/CT for neuroendocrine tumors looks like this: Not only does this scan show these tumors, it is also much faster than the older scan, and can be done during a single appointment of two to 2.5 hours.

How long does a Dotatate scan take?

This imaging takes about 40 minutes. – If your doctor asked for a whole-body scan (from the top of your head to your toes), the imaging will take about 70 minutes. Expect to be in the Imaging Department for 3 to 3½ hours for your entire PET/CT scan.

What is Octreoscan used for?

An octreotide scan (also called a somatostatin receptor scintigraphy) is a test used to check the body for neuroendocrine tumor cells. This test is done in a Nuclear Medicine department, which is a type of radiology that uses radioactive materials to diagnose or treat diseases.

How much does a gallium 68 scan cost?

As of July 2016, the US FDA has approved the use of 68-Gallium DOTATATE for PET imaging for both adult and pediatric patients and the imaging modality has become widely available in the USA. The cost of the imaging modality is about USD$4,000.00 and this cost is not yet routinely covered by insurance companies.

Who manufactures Lutathera?

Basel, October 19, 2018 – Novartis today announced presentation of a new analysis of Lutathera ® (lutetium Lu 177 dotatate*) NETTER-1 data at the 2018 European Society for Medical Oncology (ESMO) congress examining the impact of Lutathera treatment on patients with low, medium or high liver tumor burden.

What is the difference between a bone scan and a gallium scan?

For example, in a bone scan, the tracer is put into a vein in your arm about 2 hours before the test begins. For gallium scans, the tracer is given a few days before the test.

What is Dotatate therapy?

Lu-DOTATATE therapy is an important treatment option in somatostatin receptor type-2-positive pancreatic, nonpancreatic gastroenteropancreatic-NETs, and lung NETs including metastatic NETs with an unknown primary site and significantly contributed to patients’ OS.

What does a Dotatate PET scan look for?

What is a PET/CT Ga-68 dotatate scan? This scan is done to diagnose neuroendocrine tumors, which involve both the nervous system and the endocrine glands. For the scan, we will inject a radioactive substance called a tracer into your vein. The tracer used for this scan is called Ga-68 dotatate.