How is Udpga formed?
How is Udpga formed?
The UDPGA is formed in the cytosol from glucose-1-phosphate in a two-step reaction (figure 4.48). The first step, addition of the UDP, is catalysed by UDP glucose pyrophosphorylase, the second step by UDP glucose dehydrogenase.
How is UDP Glucuronate formed?
UDP-glucuronic acid is formed from UDP-glucose by oxidation of its glucose moiety. UDP-glucuronate reacts with metabolic waste products and drugs; this results in a water-soluble conjugate called a glucuronide.
What is conjugation with glucuronic acid?
Conjugation with glucuronic acid is the major route for the biotransformation and elimination of carboxylic acid-containing drugs [1,2]. Under normal conditions, acyl glucuronides are formed primarily in the liver and excreted predominantly through the urine in humans (Fig. 3-3).
What is uronic acid pathway?
Uronic acid pathway is an alternative oxidative pathway for glucose metabolism. It catalyzes the conversion of glucose to glucuronic acid, ascorbic acid, and pentoses. It does not lead to the formation of ATP.
What is the full form of Udpg?
UDPG may refer to: Uridine diphosphate glucose. Uridine diphosphate glucuronic acid.
Which compound is detoxified by glucuronidation reaction?
8- Which of the following compounds is detoxified by Glucuronidation reactions? Methanol.
What is the role of UDP glucose?
Functions. UDP-glucose is used in nucleotide sugar metabolism as an activated form of glucose, a substrate for enzymes called glucosyltransferases. UDP-glucose can also be used as a precursor of sucrose, lipopolysaccharides and glycosphingolipids.
Is UDP an IP?
User Datagram Protocol (UDP) – a communications protocol that facilitates the exchange of messages between computing devices in a network. It’s an alternative to the transmission control protocol (TCP). In a network that uses the Internet Protocol (IP), it is sometimes referred to as UDP/IP.
What is the benefit of conjugation?
The genetic material transferred during conjugation often provides the recipient bacterium with some sort of genetic advantage. For instance, in many cases, conjugation serves to transfer plasmids that carry antibiotic resistance genes.
Which drugs are metabolized by glucuronide conjugation?
Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages involve glycosidic bonds.
