What is the role of piperazine in drug design and development?
What is the role of piperazine in drug design and development?
Among nitrogen heterocycles, the piperazine motif has attracted considerable attention as its double nitrogen atom and hydrogen in water can form a hydrogen bond effect; thus, it has good hydrophilicity and can significantly increase the water solubility of the drug, while also improving the biological activity and …
Is example of piperazine derivatives?
The piperazine derivatives include 1-benzylpiperazine (BZP), 1,3-trifluoromethylphenylpiperazine (TFMPP), 1-(3-chlorophenyl) piperazine (mCPP) and 1-(4-methoxyphenyl) piperazine (MeOPP); a full summary of their chemical properties is presented in the ‘Physical Descriptions’ section.
What is piperazine ring?
Piperazine (/paɪˈpɛrəziːn/) is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste.
What is the use of piperazine?
Piperazine belongs to the family of medicines called anthelmintics. Anthelmintics are used in the treatment of worm infections. Piperazine is used to treat: common roundworms (ascariasis) and.
How do you use piperazine?
Proper use of piperazine
- Dissolve the contents of 1 packet of granules in 57 mL (about 2 ounces) of water, milk, or fruit juice.
- Be sure to drink all of the liquid to get the full dose of medicine.
What is the best anthelmintic?
For general human chemotherapy against STHs, ALB is superior to all the other anthelmintics tested here and is considered the single best anthelmintic.
What is piperazine used to treat?
Piperazine is a medication used to treat roundworm and pinworm. Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953.
What are the uses of diphenylmethane?
Diphenylmethane uses and side effect Reference – Gastrointestinal tract Anorectal Antacids Anti Diarrhoeals Anti Spasmodic Anti Ulcer Colon & Rectum Enzymes and Carminatives H2 Blockers Laxatives Purgatives Probiotics Medicines containing Diphenylmethane
What is the structure of piperazine?
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound.
What is the difference between anthelmintics and piperazine?
Anthelmintics are used in the treatment of worm infections. Piperazine is used to treat: pinworms (enterobiasis; oxyuriasis). Piperazine works by paralyzing the worms. They are then passed in the stool. Piperazine is available only with your doctor’s prescription.
