What does CYP26B1 do?
What does CYP26B1 do?
Cytochrome P450 26B1 is a protein that in humans is encoded by the CYP26B1 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids.
Where is CYP26B1 produced?
testicular Sertoli cells
After birth, CYP26B1 is downregulated and RA produced by the testicular Sertoli cells acts upon RAREs of spermatogonia, prompting them to differentiate into primary spermatocytes that enter meiosis (Saba et al., 2014).
What is the CYP26B1 gene?
Cytochrome P450 26B1 is a protein that in humans is encoded by the CYP26B1 gene. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids.
What is the function of CYP26B1 in meiosis?
CYP26B1 maintains low levels of retinoic acid in the developing testes that blocks entry into meiosis and acts as a survival factor to prevent apoptosis of male germ cells. meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis
Are CYP26A1 and CYP 26B1 mRNA expression correlated across tissues?
The mRNA expression of CYP26A1 and CYP26B1 correlated between human tissues except for human cerebellum in which CYP26B1 was the predominant CYP26 and liver in which CYP26A1 dominated.
Are CYP26B1 mRNA levels different in the adult cerebellum?
CYP26B1 mRNA levels were approximately twice the level in adult cerebellum compared to adult whole brain samples. CYP26B1 levels were 10x higher in earlier gestational times than in later gestational times. Mouse studies identified different expression patterns of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during development.
