Which drugs are enzyme inducers?
Which drugs are enzyme inducers?
Enzyme-inducing antiepileptic drugs
- Carbamazepine.
- Eslicarbazepine acetate.
- Oxcarbazepine.
- Perampanel (at a dose of 12 mg daily or more).
- Phenobarbital.
- Phenytoin.
- Primidone.
- Rufinamide.
What drugs are CYP3A inducers?
CYP3A inducers include the glucocorticoids, rifampin, carbamazepine, phenobarbital, and phenytoin. Among the many significant CYP3A inhibitors are grapefruit juice, erythromycin, ketoconazole, clarithromycin, and verapamil.
Is efavirenz an enzyme inducer?
Efavirenz has been well described to induce drug-metabolising enzymes and decrease plasma concentrations of a number of antiretrovirals and supportive medications [14].
What are liver enzyme inducers?
Certain medicines used to treat epilepsy, HIV, tuberculosis and the herbal medicine, St John’s Wort are known as liver enzyme inducers.
How many cytochrome P450 enzymes are there?
Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 percent of drugs, with the two most significant enzymes being CYP3A4 and CYP2D6.
Is dexamethasone a CYP3A4 inducer?
Dexamethasone is a steroidal antiinflammatory agent which is used e.g. in the treatment of chronic inflammatory and autoimmune diseases. It is also effective as an antiem- etic agent in cancer chemotherapy. In cultures of human hepatocytes, dexamethasone is a potent inducer of CYP3A4 (Pichard et al.
What are some common medications classified as weak, moderate and strong inhibitors of CYP3A4?
Common Medications Classified as Weak, Moderate and Strong Inhibitors of CYP3A4. Strong inhibitors of CYP3A4 include: Clarithromycin , telithromycin, nefazodone, itraconazole, ketoconazole, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir.
What drugs are CYP3A4 inhibitors?
CYP3A4 Inhibitors. Some drugs, such as clarithromy- cin, itraconazole, ketoconazole, nefazo- done, nelfinavir, and ritonavir , are particu- larly potent inhibitors of CYP3A4; patients on these drugs may have markedly reduced CYP3A4 activity.
What are strong CYP3A4 inhibitors?
Strong inhibitors of CYP3A4 include: Clarithromycin, telithromycin, nefazodone, itraconazole, ketoconazole, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir. It is important to note that not all drugs within a class of medications are known to be inhibitors of CYP3A4.
What is a CYP3A4 inhibitor?
In 1998, various researchers showed that grapefruit juice, and grapefruit in general, is a potent inhibitor of CYP3A4, which can affect the metabolism of a variety of drugs, increasing their bioavailability. In some cases, this can lead to a fatal interaction with drugs like astemizole or terfenadine.
