What is Lkm test?

What is Lkm test?

The liver-kidney microsomal (LKM) antibodies serum test is used in the detection of LKM-1 antibodies is an aid in the diagnosis of autoimmune hepatitis, type 2 (AIH-2).

What is liver IgG test?

Background. Hypergammaglobulinemia is frequently observed in patients with chronic liver disease (CLD) of different causes. On the other hand, elevated levels of serum immunoglobulin G (IgG) are the best diagnostic marker for autoimmune hepatitis (AIH).

What is actin smooth muscle antibody test for?

The smooth muscle (SMA) or actin antibody test is primarily ordered along with antinuclear antibodies (ANA) and liver kidney microsomal type 1 (LKM-1) antibodies to help diagnose autoimmune hepatitis and to differentiate between the two major types of autoimmune hepatitis, type 1 and type 2.

What does antibodies in the liver mean?

It has been well established that numerous kinds of autoantibodies have been detected in liver disease. Some kinds of autoantibodies may be helpful in the diagnosis of autoimmune liver diseases including autoimmune hepatitis, primary biliary cirrhosis or primary sclerosing cholangitis.

What is the cost of ANA test?

ANTI NUCLEAR ANTIBODIES (ANA) Test @ Rs. 520 | DiagnosticCentres.in.

How does autoimmune hepatitis affect the body?

Autoimmune hepatitis occurs when the body’s immune system, which ordinarily attacks viruses, bacteria and other pathogens, instead targets the liver. This attack on your liver can lead to chronic inflammation and serious damage to liver cells.

What does positive actin antibody mean?

What does the test result mean? A significant increase in the blood titer of SMA or actin antibody and/or ANA is usually due to autoimmune hepatitis type 1. A small increase in SMA or actin antibody may be present in up to 50% of patients with primary biliary cholangitis (PBC).

What is Type 1 form of autoimmune hepatitis?

This disorder occurs when you have too many protein antibodies in your blood. It may be caused by a long-term (chronic) infection or certain blood diseases. Type 1 autoimmune hepatitis is linked to other disorders where the body attacks itself (autoimmune disorders). These may include: Thyroiditis.

What is positive liver disease?

A positive test on the panel may be a sign of autoimmune hepatitis or other autoimmune liver disease. If the test is positive mostly for anti-mitochondrial antibodies, you are likely to have primary biliary cholangitis.

What are LKM-1 antibodies?

Liver Kidney Microsomal (LKM-1) Antibody (IgG) – The presence of LKM-1 antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of autoimmune liver diseases such as autoimmune hepatitis (AIH-2).

What is the prevalence of LKM-1?

The disease is most common between the ages of 2 to 14 and is more frequent in females than males (8:1). LKM-1 antibodies have been reported in up to 8% of patients with chronic HCV infection. A negative LKM-1 result does not rule out the presence of autoimmune hepatitis type 2.

What does a negative LKM-1 result mean?

Pricking the needle and drawing blood is not painful. The sample collected will then be analysed. A negative LKM-1 result does not rule out the presence of autoimmune hepatitis type 2. LKM-1 may be detected in some patients as a result of HCV infection and may not be the result of AIH-2.

What does LKM stand for?

Liver-Kidney Microsomal (LKM) Antibodies TEST: 163980 CPT: 86376