What is C-MYC function?

What is C-MYC function?

c-Myc is a multifunctional transcription factor which drives the multiple synthetic functions necessary for rapid cell division while at the same time inhibiting expression of genes with antiproliferative functions. Because of its propensity to induce apoptosis, its expression is tightly regulated.

How do you pronounce C-MYC?

The viral gene is often symbolized v-myc and the cellular gene c-myc (pronounced “see-mick”).

When was c-myc discovered?

Identification of MYC In the late 1970s, an avian acute leukemia virus (MC29) was shown to promote a spectrum of malignancies, including myelocytomas, sarcomas, and importantly, carcinomas. This ability to induce carcinomas was of particular interest because this represented the most common form of human malignancy.

How do you pronounce c-myc?

What is myc pathway?

MYC family protein The structure of MYC includes the first exon that does not encode a protein, and the other is the third exon that encodes a protein. The MYC gene belongs to an oncogene encoding a nuclear protein that encodes a nuclear DNA binding protein involved in cell cycle regulation.

How many forms of Myc are there?

The Myc family includes four transcription factors, c-Myc, N-Myc, L-Myc, and S-Myc, involved in the control of cell growth, differentiation, and apoptosis.

How do you spell myc?

Myc- is a variant of myco-, which loses its –o– when combined with words or word elements beginning with vowels. The closely related combining forms myceto- and -mycete both also indicate “mushroom, fungus.” The combining form -mycin used in the names of antibiotics, usually those derived from fungi. Want to know more?

How does Myc cause apoptosis?

c-MYC represses some of the survival pathways associated with death receptor and DISC activation, and this can promote apoptosis. Death receptor signaling can activate the nuclear factor-κB (NF-κB) transcription factor, which suppresses receptor-induced apoptosis.

Why is myc Hard Target?

Second, the structure of the Myc protein itself does not have preferred binding pocket for traditional drug modalities. Myc protein lacks the catalytic clefts, and thus, has no feasible or effective drug-binding pockets for traditional small molecule drugs.

What is the difference between c-Myc and Myc?

With respect to myc, it can refer to the family of MYC transcription factor proteins (of which, c-Myc, L-myc and N-myc are members). More commonly, myc refers to c-Myc, and is the name given to a 10-amino acid segment of human proto-oncogene myc (EQKLISEEDL) and is a common epitope added to recombinant DNA for making fusion proteins.

What is the v-myc oncogene?

While many cancers are considered to be c-MYC driven cancers, such as breast cancer, some forms of cancer are attributed to v-MYC, which is a viral homolog of the c-MYC gene. The v-MYC oncogene forms when several acute transforming retroviruses interact with mutated c-MYC genes.

Is myc1 and MYC2 the same protein?

Myc1 and myc2 are considered MYC isoforms because these proteins have a similar, but not identical amino acid sequence. However, when it comes to the MYC gene, Uniprot, which is known in the scientific community as a comprehensive, high-quality protein sequence resource, shows eight more potential isoforms in the MYC gene.

What is the MYC family of human transcription factors?

The Myc family of human transcription factors was identified after discovering homology between an oncogene carried by the Avian virus, Myelocytomatosis (v-myc), and cellular Myc (c-Myc), a human gene that is often over-expressed in several cancers. Two further transcription factors, n-Myc and l-Myc, were later added to the family.