What cells are CD154 expressed on?
What cells are CD154 expressed on?
CD154 is also expressed on CD4 thymocytes, activated CD8 T cells, NK cells, monocytes, basophils, mast cells, activated eosinophils, and activated platelets. Newborn T cells are deficient in CD154 expression, although they can be induced to express the antigen if strongly stimulated.
What does cdcd137+CD154 stand for?
CD137+CD154− Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures. Regulatory T cells (Tregs) are an attractive therapeutic tool for several different immune pathologies.
Is cdcd154 a marker of CD4 T-cell function in chronic hepatitis C?
CD154, a marker of antigen-specific stimulation of CD4 T cells, is associated with response to treatment in patients with chronic HCV infection CD4 T-cell function is crucial for the eradication of HCV, and insufficient function is observed in chronic carriers.
What is the target antibody for cdcd154?
CD154 was targeted by BG9588, a humanized antibody, 25 in patients with proliferative lupus nephritis. This small trial of 28 patients was prematurely terminated because of an increased incidence of thrombosis (two myocardial infarctions).
https://www.youtube.com/watch?v=ep49BzIh67o
What is cdcd154 made of?
CD154 is a type II membrane glycoprotein that mediates cell activation via interaction with CD40. It folds into a tissue necrosis factor (TNF)-homologous globular domain (shown here), a long extracellular stalk, a short transmembrane segment, and a small cytoplasmic domain.
What is the prognosis of cdcd154 deficiency?
CD154 deficiency in mice results in decreased CD4+ and CD8+ T cell responses to viral antigens and increased mortality after HSV-1 footpad infection. In studies of HSV corneal infection, the numbers of CD4+ and CD8+ T cells and B cells within draining lymph nodes dramatically expand within the first 7 days.
