Is squamous cell carcinoma positive for CK7?
Is squamous cell carcinoma positive for CK7?
Positivity for any neuroendocrine marker was seen in 5 (8%) cases of squamous cell carcinoma and 14 (12%) cases of adenocarcinoma (of which 3 cases were positive in 2 markers). Squamous cell carcinoma positive for cytokeratin 7 (CK7).
What does CDX2 negative mean?
CDX2-negative tumors are often associated with an increased likelihood of aggressive features, including advanced stage, poor differentiation, and vascular invasion and BRAF mutation.
What does positive for CDX2 mean?
These results suggest that positive CDX2 staining represents a highly sensitive and specific marker of metastatic colorectal carcinoma in both biopsy and resected specimens, and is superior to staining for the CK7-/20+ phenotype.
What does positive CK7 mean?
For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.
Does CK7 and CK19 expression predict aggressive tumor phenotypes in interstitial cancer?
Results: Both CK7 and CK19 expression were significantly up-regulated in ICC compared to their non-tumor counterparts, and positively correlated with aggressive tumor phenotypes, like lymph node metastasis and larger tumor size. Furthermore, high expression of either CK7 or CK19 predicted a significantly dismal postoperative survival.
Is CK19 positive in pancreatic cancer?
It is recommended that CK19 be part of the immunohistochemical panel in the work-up of pancreatic endocrine tumors. CK19 is positive in the most of neuroendocrine tumors occurring in the rest of the GIT, except rectal tumors, which are negative.
Are CK7 and CK19 positive endocervical reserve cells progenitor cells of cervical cancer?
Thus, CK19 and CK7 positive endocervical reserve cells were suggested as progenitor cells of cervical cancer [ 8, 9] before the concept of SCJ cell emerged. Despite this common expression of CK7 and CK19 in the normal cervix and cervical neoplasia, little is known about the association between CK7 and CK19 and HPV in cervical carcinogenesis.
Is ck7/ck19 index a prognostic factor for intrahepatic cholangiocarcinoma?
CK7/CK19 index: A potential prognostic factor for postoperative intrahepatic cholangiocarcinoma patients CK7/CK19 index was an independent adverse prognostic factor for ICC patients’ survival, and may be helpful to improve postoperative risk stratification and individualized treatment strategies.
