What is the basal compartment?
What is the basal compartment?
The blood-testis barrier (BTB) is composed of highly polarized Sertoli cells and divides the seminiferous epithelium (functional unit of the testis) into a basal compartment (outer compartment, in contact with blood and lymph) and apical compartment (inner compartment, protected from blood and lymph) (Su et al., 2011).
Where is the spermatogenesis occur in?
seminiferous tubules
Spermatogenesis is a complex, strictly regulated process that takes place inside the seminiferous tubules of the testis. The process includes the proliferation of male germ cells, meiosis, and finally the haploid differentiation, which is characterized by dramatic morphological changes.
What is the function of the blood-testis barrier?\?
Thus, the function of the blood-testis barrier is to sequester germ cells residing in the adluminal compartment from the circulatory and lymphatic systems, and together with local immune suppression, to provide an immunoprivileged microenvironment for the completion of meiosis (for reviews, see Refs.
Where is the Adluminal compartment?
The barrier is formed by tight junctions, adherens junctions and gap junctions between the Sertoli cells, which are sustentacular cells (supporting cells) of the seminiferous tubules, and divides the seminiferous tubule into a basal compartment (outer side of the tubule, in contact with blood and lymph) and an …
What cell types are in the basal compartment compared to the Adluminal compartment?
The spermatogonia remain in the basal compartment while the spermatocytes are located in the adluminal compartment. Primary spermatocytes are located in the middle region of the seminiferous tubule, within the adluminal compartment. These cells have a prolonged prophase that gives rise to the first meiotic division.
Which of these is the correct sequence in spermatogenesis?
Spermatogonia → Spermatids → Secondary spermatocytes → Primary spermatocytes → sperms.
What are the stages of spermatogenesis?
The process of germ cell development during spermatogenesis can be divided into five succesive stages: (1) spermatogonia, (2) primary spermatocytes, (3) secondary spermatocytes, (4) spermatids, and (5) spermatozoa.
What happens if blood-testis barrier is damaged?
When the blood–testes barrier is breached, and sperm enters the bloodstream, the immune system mounts an autoimmune response against the sperm, since the immune system has not been tolerized against the unique sperm antigens that are only expressed by these cells.
Which of the following best describes the blood testes barrier?
Which of the following best describes the function of the blood-testis barrier? The blood-testis barrier maintains a differential fluid composition of the seminiferous tubule lumen that facilitates the development of sperm and blocks the access of androgens to the lumen.
What do the Sustentacular cells secrete?
It is located in the walls of the seminiferous tubules and supplies nutrients to sperm. They are responsible for the differentiation of spermatids, the maintenance of the blood-testis barrier, and the secretion of inhibin, androgen-binding protein and Mullerian-inhibiting factor.
Which is correct about spermatogenesis and oogenesis?
Spermatogenesis results in only 1 sperm; oogenesis results in 4 eggs. Correct answer: Spermatogenesis results in 4 sperm; oogenesis results in only 1 egg. In oogenesis, a primary oocyte will become 1 functioning ovum (or egg) while 3 polar bodies are also produced, which are nonfunctioning and never become eggs.
What is the difference between basal compartment and adluminal compartment?
The basal compartment comprises the interstitial space and the spaces occupied by the spermatogonia. The adluminal compartment comprises the tubule lumen and the intercellular spaces down to the level of the occluding junctions (OJ). In this compartment are spermatocytes, spermatids, and spermatozoa.
What are the different muscle compartments of the thigh?
Surrounding the centrally located femur are three intermuscular septa, creating divisions between the anterior, posterior, and medial compartments of the thigh. The different muscle compartments of the thigh The anterior compartment consists of muscles that contract to flex the hip and extend the knee.
What are the intermuscular septa of the thigh?
Surrounding the centrally located femur are three intermuscular septa, creating divisions between the anterior, posterior, and medial compartments of the thigh. The anterior compartment consists of muscles that contract to flex the hip and extend the knee.
What muscles are involved in the anterior compartment?
The anterior compartment consists of muscles that contract to flex the hip and extend the knee. Iliopsoas travels from the abdomen and pelvis into the thigh to flex the hip, the vastus muscles extend the knee, and rectus femoris and sartorius act on both joints.
