What is Talzenna used for?
What is Talzenna used for?
TALZENNA is a prescription medicine used to treat adults with a certain type of breast cancer (gBRCA-mutated, HER2-) that has spread to other parts of the body (locally advanced or metastatic).
What is Talazoparib used for?
Talazoparib is used to treat certain types of breast cancer that has spread within the breast or to other areas of the body. Talazoparib is in a class of medications called poly (ADP-ribose) polymerase (PARP) inhibitors. It works by stopping or slowing the growth of cancer cells.
Is Talazoparib FDA approved?
On October 16, 2018, the FDA approved talazoparib (Talzenna; Pfizer), an oral PARP inhibitor, for the treatment of adults with deleterious or suspected deleterious germline BRCA mutation–positive, HER2-negative locally advanced or metastatic breast cancer.
How much does Talazoparib cost?
The cost for Talzenna oral capsule 0.25 mg is around $5,364 for a supply of 30 capsules, depending on the pharmacy you visit….Oral Capsule.
| Quantity | Per unit | Price |
|---|---|---|
| 30 | $178.79 | $5,363.67 |
Does Talazoparib cause hair loss?
Hair loss was another side effect of talazoparib. While the percentage of women who experienced hair loss was about the same in the two treatment groups, women treated with talazoparib had milder hair loss than women treated with chemotherapy.
What are the side effects of Talazoparib?
Side Effects
- Black, tarry stools.
- blood in the urine or stools.
- chest pain.
- hoarseness.
- pinpoint red spots on the skin.
- swelling or inflammation of the mouth.
- swollen glands.
- troubled breathing with exertion.
How effective is Talazoparib?
The median overall survival at the interim analysis was 22.3 months (95% CI, 18.1 to 26.2) in the talazoparib group and 19.5 months (95% CI, 16.3 to 22.4) in the standard-therapy group (hazard ratio for death, 0.76; 95% CI, 0.55 to 1.06, P=0.11) (Figure 2).
Is Talazoparib cytotoxic?
4.2. Talazoparib exhibits cytotoxic activity at a lower concentration and is more potent at trapping PARP-DNA complexes when compared with other PARP inhibitors (Wang et al., 2016a).
Is Talazoparib an immunotherapy?
Immunotherapy with monoclonal antibodies, such as avelumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Talazoparib and axitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Who owns Talzenna?
Company: Pfizer Inc.
What is Talzenna (talazoparib)?
Talzenna (talazoparib) is is a prescription medicine used to treat HER2-negative breast cancer.
What are the side effects of Talzenna?
” The most common side effects of Talzenna include: 1 tiredness or weakness 2 low number of red or white blood cells 3 nausea 4 low number of platelets 5 headache
Do you need a prescription for Talzenna?
Talzenna can only be obtained with a prescription and treatment should be started and supervised by a doctor experienced in the use of cancer medicines. Talzenna is available as capsules (1 mg and 0.25 mg) and the recommended dose is 1 mg once a day.
Is Talzenna authorised in the European Union?
This medicine is authorised for use in the European Union. Talzenna is a cancer medicine used on its own to treat a type of breast cancer (HER2-negative with BRCA mutations) that has spread beyond the original site, in patients who have been treated with certain medicines which have stopped working or when these medicines are not suitable.
