What is focal foveolar hyperplasia?
What is focal foveolar hyperplasia?
Foveolar hyperplasia is a rare disorder characterized by an overgrowth of mucous cells in the stomach. In children, it may present as a localized lesion that affects the antrum primarily, called focal foveolar hyperplasia (FFH), or as a diffuse lesion, known as Ménétrier disease.
What does mild foveolar Hyperplasia mean?
Foveolar hyperplasia – Hyperplasia is a word pathologists use to describe an increased number of cells. Foveolar hyperplasia means there is an increased number of foveolar cells on the inside surface of the stomach. The increased number of cells causes the glands to look twisted.
What is foveolar?
Foveolar cells or surface mucous cells are mucus-producing cells which cover the inside of the stomach, protecting it from the corrosive nature of gastric acid. These cells line the gastric mucosa (mucous neck cells are found in the necks of the gastric pits).
What is polypoid foveolar hyperplasia?
Polypoid foveolar hyperplasia (PFH) is regarded as a precursor of gastric hyperplastic polyps and differs slightly from them in the microscopic structure. Elongated pits of the mucosa but without features of dilatation can be also seen in PFH, and the lamina propria is either normal or only slightly swollen[2].
What causes Foveolar hyperplasia?
Aims: In the gastric antrum and body, foveolar hyperplasia is a feature of reactive gastritis resulting from–for example, duodenogastric bile reflux and the use of non-steroidal anti-inflammatory drugs (NSAIDs).
What is focal Foveolar metaplasia?
Abstract. Foveolar gastric metaplasia of the duodenum (FGM) is considered as imperfect mucosal healing in the context of H. pylori gastritis and intake of NSAIDs or ASS. Typical endoscopic findings are redness of the mucosa, erosion/ulcer and loss of mucosal folds.
What causes foveolar hyperplasia?
What do foveolar cells do?
Foveolar cells, which secrete mucin, line the surface of the stomach and the gastric. These are tall and columnar cells that contain clear mucin-containing granules. Neck cells are located in the gastric pits, which are probably progenitor foveolar cells.
What is metaplasia why does it occur?
Metaplasia is the replacement of normal cells with a secondary, but nonneoplastic, population. Metaplasia can occur in response to hormonal or growth factor alterations or as part of an adaptive response to protect against chronic irritation.
