What are B cells derived from?

What are B cells derived from?

B cells develop from hematopoietic stem cells (HSCs) that originate from bone marrow. HSCs first differentiate into multipotent progenitor (MPP) cells, then common lymphoid progenitor (CLP) cells.

What is the definition of B lymphocytes?

A type of white blood cell that makes antibodies. B lymphocytes are part of the immune system and develop from stem cells in the bone marrow. Also called B cell.

Where do B cell lymphocytes originate?

Both B and T lymphocytes originate in the bone marrow but only B lymphocytes mature there; T lymphocytes migrate to the thymus to undergo their maturation. Thus B lymphocytes are so-called because they are bone marrow derived, and T lymphocytes because they are thymus derived.

What do B lymphocytes differentiate into?

When stimulated by antigen, B cells undergo a series of changes in cell surface structures and in functional capabilities and differentiate into plasma cells. Plasma cells, the final stage in B cell differentiation, secrete large amounts of immunoglobulin.

How are B lymphocytes formed?

Like T cells, B cells are formed from multipotent hematopoietic stem cells (HSCs) in the bone marrow and follow a pathway through lymphoid stem cell and lymphoblast (see Figure 1 in Cellular Defenses).

What are the types of B lymphocytes?

There are four main B cell types: transitional, naïve, plasma, and memory cells.

What are the function of lymphocytes?

Lymphocytes are white blood cells uniform in appearance but varied in function and include T, B, and natural killer cells. These cells are responsible for antibody production, direct cell-mediated killing of virus-infected and tumor cells, and regulation of the immune response.

What is the major function of lymphocytes?

Lymphocytes are cells that circulate in your blood that are part of the immune system. There are two main types lymphocytes: T cells and B cells. B cells produce antibody molecules that can latch on and destroy invading viruses or bacteria.

What causes B cells to differentiate into B plasma cells?

The antigen-dependent phase of B cell development occurs following B cell activation by antigen binding and co-stimulation. These signals promote B cell differentiation into either memory B cells or terminal, antibody-secreting plasma cells.

What is the function of B cells in the body?

B cells are at the centre of the adaptive humoral immune system and are responsible for mediating the production of antigen-specific immunoglobulin (Ig) directed against invasive pathogens (typically known as antibodies).