What is TIM23?
What is TIM23?
Tim23, a key component of the mitochondrial preprotein translocase, is anchored in the inner membrane by its C-terminal domain and exposes an intermediate domain in the intermembrane space that functions as a presequence receptor.
What would be the effect of a mutation in the TIM23 complex?
Mutations of Tim23 and Tim50 that disrupt the interaction between the two proteins lead to temperature-sensitive (ts) growth defects and impair translocation of proteins through the TIM23 complex20,24.
What is the function of TIM proteins?
The translocase of the inner membrane (TIM) is a complex of proteins found in the inner mitochondrial membrane of the mitochondria. Components of the TIM complex facilitate the translocation of proteins across the inner membrane and into the mitochondrial matrix.
What is the function of the TOM complex?
The TOM complex is responsible for a number of functions: first, it is responsible for the recognition of precursor proteins via cytosolic-faced receptor components; second, it is responsible for translocation of protein across the outer membrane via the Tom40 channel; and third, it mediates the transfer of proteins …
What is Tim biochemistry?
The TIM/TOM complex is a protein complex in cellular biochemistry which translocates proteins produced from nuclear DNA through the mitochondrial membrane for use in oxidative phosphorylation. The vast majority of proteins destined for the mitochondria are encoded in the nucleus and synthesized in the cytoplasm.
What is Tom biochemistry?
The translocase of the outer membrane (TOM) is a complex of proteins found in the outer mitochondrial membrane of the mitochondria. It allows movement of proteins through this barrier and into the intermembrane space of the mitochondrion.
How many proteins encoded by nuclear DNA are destined for the mitochondria?
The mitochondrial genome (mtDNA) encodes for 13 proteins, 22 tRNAs, and 2 rRNAs.
What does Tom complex do?
What is Tom biology?
The TIM/TOM complex is a protein complex in cellular biochemistry which translocates proteins produced from nuclear DNA through the mitochondrial membrane for use in oxidative phosphorylation….TIM/TOM complex.
| mitochondrial protein-transporting ATPase | |
|---|---|
| Identifiers | |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
What is a DNA Translocase?
DNA translocases are motor proteins that convert the chemical energy of ATP hydrolysis into directional movement along DNA. We have used DNA curtains to study the movement of the motor proteins RecBCD and FtsK.
Where is the Translocase located?
the mitochondria
The translocase of the outer membrane (TOM) is a complex of proteins found in the outer mitochondrial membrane of the mitochondria. It allows movement of proteins through this barrier and into the intermembrane space of the mitochondrion.
