What causes mitotic catastrophe?

What causes mitotic catastrophe?

Mitotic catastrophe (MC) has long been considered as a mode of cell death that results from premature or inappropriate entry of cells into mitosis and can be caused by chemical or physical stresses.

Does radiation cause apoptosis or necrosis?

Radiation therapy is one of the cornerstones of cancer treatment. In tumor cells, exposure to ionizing radiation (IR) provokes DNA damages that trigger various forms of cell death such as apoptosis, necrosis, autophagic cell death, and mitotic catastrophe.

Which checkpoint in the cell cycle is affected by docetaxel?

In contrast, low concentrations of docetaxel will affect the dynamics of microtubules, inducing a transient activation of the spindle-assembly checkpoint.

What happens mitotic catastrophe?

Mitotic catastrophe would be a type of cell death occurring during mitosis, as a result of DNA damage or deranged spindle formation coupled to the debilitation of different checkpoint mechanisms that would normally arrest progression into mitosis and hence suppress catastrophic events until repair has been achieved.

What is mitotic delay?

From Wikipedia, the free encyclopedia. Mitotic catastrophe refers to a mechanism of delayed mitosis-linked cell death, a sequence of events resulting from premature or inappropriate entry of cells into mitosis that can be caused by chemical or physical stresses.

What is the difference between necroptosis and necrosis?

Necrosis is a form of cell death which results in the unregulated digestion of cell components [1]. In direct contrast to the unregulated necrosis type cell-death event, necroptosis represents an example of a regulated version of the necrotic cell death pathway.

When cells bypass checkpoints what is the consequence?

If the checkpoint mechanisms detect problems with the DNA, the cell cycle is halted, and the cell attempts to either complete DNA replication or repair the damaged DNA. If the damage is irreparable, the cell may undergo apoptosis, or programmed cell death 2.

What happens prior to the cell being allowed to enter the G2 stage of the cell cycle?

After cell growth during the G1 phase and DNA replication during the S phase, the cell is ready to enter the G2 phase. Before the G2 phase can start, each chromosome of the cell must have been duplicated, and the proteins required for the extra cell membranes and cell structures must be present.

What is mitotic catastrophe (MC)?

Mitotic catastrophe (MC) is a mechanism of delayed mitotic-linked cell death resulting from aberrant mitosis, although there is an ongoing debate over whether MC is a specific type of cell death or a process preceding death by apoptosis or necrosis.20

What is mitotic catastrophe in epithelial tumors?

Mitotic catastrophe is a cell death mechanism, which occurs as a result of dysregulated/failed mitosis that may be accompanied by morphological alterations, including micronucleation, multinucleation and abnormal mitoses. In this review, the morphologic features of TN in malignant epithelial tumors are investigated.

What are the consequences of a failed mitosis?

The induction of other cell death pathways due to a failed mitosis has three different consequences: (1) cell death during mitosis; (2) cell death once a cell has exited mitosis; and (3) senescence following exit from mitosis [51].

What is the role of nocodazole in mitosis?

Nocodazole is a compound that inhibits microtubule polymerization and is widely used as a positive control for mitotic cells in the laboratory because it arrests cells in mitosis. Entry into mitosis with damaged DNA induces mitotic catastrophe through the SAC.