Is fosfomycin a broad-spectrum antibiotic?

Is fosfomycin a broad-spectrum antibiotic?

Fosfomycin is a broad-spectrum antibiotic discovered in Spain in 1969. It has bactericidal activity against a wide range of bacteria, including gram-negative micro-organisms and some gram-positive bacteria, such as staphylococci.

What bacteria does fosfomycin cover?

Fosfomycin presents good activity against Gram-negative bacteria such as Haemophilus influenzae and most enterobacteria (figure 1), including Citrobacter spp., Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Serratia marcescens and Shigella spp.

What class of antibiotics is fosfomycin?

Abstract: Fosfomycin (C3H7O4P) is a phosphonic acid derivative representing an epoxide class of antibiotics. The drug is a re-emerging bactericidal antibiotic with a wide range of actions against several Gram-positive and Gram-negative bacteria.

Is fosfomycin broad or narrow spectrum?

Fosfomycin is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis.

Is fosfomycin a good antibiotic for UTI?

Fosfomycin is a safe and effective antibacterial drug for urinary tract infections, but its use should be limited to delay the development of resistance. It will prove to be a useful treatment option for community-based treatment of patients with resistant organisms.

Is fosfomycin a type of penicillin?

Fosfomycin is a broad spectrum antibiotic used to treat uncomplicated urinary tract infections. Fosfomycin was discovered in 1969 by scientists at the Spanish Penicillin and Antibiotics Company and is produced by Streptomyces fradiae.

Is fosfomycin a penicillin?

Is fosfomycin antibiotic?

Fosfomycin is used to treat urinary tract infection and cystitis (bladder infection) in women. This medicine is an antibiotic. It works by killing bacteria or preventing their growth.

Is fosfomycin a broad spectrum antibiotic?

8.1 Pharmacology. Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum -containing anti-tumor agents.

Does fosfomycin kill Klebsiella?

Fosfomycin Fosfomycin is a synthetic, broad-spectrum, bactericidal antibiotic with in vitro activity against large numbers of gram-negative and gram-positive organisms including E. coli, Klebsiella spp, Proteus spp, Pseudomonas spp, and VRE. It does not have activity against Acinetobacter

What does funfosfomycin do to MRSA?

Fosfomycin has a broad spectrum of activity against both gram-positive and gram-negative organisms, including many antibiotic-resistant organisms such as Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) Enterococcus species, including vancomycin -resistant enterococci (VRE)

Can fosfomycin be used for urinary tract infection?

Indications. Oral fosfomycin should be used only for uncomplicated (ie, lower) UTIs caused by susceptible pathogens. However, because it has a broad spectrum of activity, IV fosfomycin is sometimes used to treat infections with multidrug-resistant organisms at other anatomic sites.