What kind of diuretic is acetazolamide?
What kind of diuretic is acetazolamide?
Acetazolamide is the only carbonic anhydrase inhibitor with significant diuretic effects. It is readily absorbed and undergoes renal elimination by tubular secretion. Its administration is ordinarily marked by a brisk alkaline diuresis.
What drug is a thiazide diuretic?
Three thiazide diuretics are the most commonly used: hydrochlorothiazide (HCTZ), chlorthalidone, and indapamide. HCTZ and chlorthalidone are FDA-approved for clinical use in the management of primary hypertension.
Why is acetazolamide a diuretic?
The diuretic effect of acetazolamide is due to its action in the kidney on the reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. The result is renal loss of bicarbonate (HCO3 ion), which carries out sodium, water, and potassium.
Is acetazolamide a potent diuretic?
Conclusion. Acetazolamide is a potent candidate “chloride-regaining diuretic” through the exchange between chloride and bicarbonate in the nephron [13, 16, 18] for treating HF patients under the “chloride theory” [9].
Is acetazolamide sulfa based?
Acetazolamide has recently been used for hemiplegic migraine and idiopathic intracranial hypertension. Acetazolamide is a nonbacteriostatic sulfonamide that contains a sulfonamide functional group but lacks antibiotic activity.
Does acetazolamide lower potassium?
This drug may reduce the potassium levels in your blood. Your doctor may recommend that you eat foods rich in potassium (such as bananas or orange juice) while you are taking this medication. Your doctor may also prescribe a potassium supplement for you to take during treatment.
What does thiazide do to urine?
Thiazides increase urine output by inhibiting the NaCl cotransporter on the luminal membrane of the earliest portion of the distal convoluted tubule, often called the cortical diluting segment (Fig. 9-5).
Is acetazolamide a weak diuretic?
The diuretic action of acetazolamide is therefore weak and not clinically useful. Acetazolamide has a role in prevention and treatment of altitude sickness (discussed later) and in glaucoma (see Chapter 50).
Can you give acetazolamide with sulfa allergy?
In summary, the risk of reaction to acetazolamide in a patient with sulfonamide allergy is low. However, acetazolamide is listed as possibly cross-reacting with sulfonamide in drug information and the package insert.
Which diuretics are safe and effective for patients with a sulfa allergy?
Diuretics that do not contain a sulfonamide group (eg, amiloride hydrochloride, eplerenone, ethacrynic acid, spironolactone, and triamterene) are safe for patients with an allergy to sulfa.
Can I drink alcohol while taking acetazolamide?
Not recommended: Avoid drinking alcohol while you are taking prednisone. As a general rule of thumb, if there is any doubt at all, it is best to refrain from mixing alcohol with medication. Hope it make sense. …Read more.
Can I take acetazolamide and drink alcohol?
Care should be taken when driving or operating machinery after taking Diamox (Acetazolamide) as it can make you feel drowsy and cause dizziness. It is advisable not to drink alcohol or to reduce your alcohol consumption when taking Diamox (Acetazolamide) as it can make the side effects stronger.
What is the therapeutic action of acetazolamide?
Acetazolamide reduces the activity of a protein in your body called carbonic anhydrase. Blocking this protein can help reduce the build-up of certain fluids in the body. Acetazolamide is used in people with certain types of glaucoma to reduce the amount of fluid in the eye, which decreases pressure inside the eye.
What conditions does acetazolamide treat?
To remove extra fluid from the body (diuresis) in people with heart failure.
