What causes advanced osteoporosis?
What causes advanced osteoporosis?
A lifelong lack of calcium plays a role in the development of osteoporosis. Low calcium intake contributes to diminished bone density, early bone loss and an increased risk of fractures. Eating disorders. Severely restricting food intake and being underweight weakens bone in both men and women.
Does lack of vitamin D cause osteoporosis?
The consequences of vitamin D deficiency are secondary hyperparathyroidism and bone loss, leading to osteoporosis and fractures, mineralization defects, which may lead to osteomalacia in the long term, and muscle weakness, causing falls and fractures.
Which hormone is responsible for osteoporosis?
Parathyroid hormone (PTH) is an important contributor to the bone remodeling process. High levels of PTH can activate osteoclasts and cause excessive bone breakdown. Calcium in your blood triggers the release of PTH.
What are types of secondary osteoporosis?
Glucocorticoid-induced osteoporosis (GIO) is the most common form of secondary osteoporosis. Although endogenous hypercortisolism or Cushing’s syndrome can be associated with bone loss, most of the patients suffering from GIO receive glucocorticoids for the treatment of a variety of diseases.
What medications can cause secondary osteoporosis?
The medications most commonly associated with osteoporosis include phenytoin, phenobarbital, carbamazepine, and primidone. These antiepileptic drugs (AEDs) are all potent inducers of CYP-450 isoenzymes.
Why do glucocorticoids cause osteoporosis?
Glucocorticoids decrease the function of the remaining osteoblasts directly and indirectly through the inhibition of insulin-like growth factor I expression. The stimulation of bone resorption is likely responsible for the initial bone loss after glucocorticoid exposure.
What vitamin is good for bones?
Getting enough calcium and vitamin D in your diet can help maintain bone strength and lessen your risk of developing osteoporosis.
What are the secondary causes of osteoporosis?
Secondary causes of osteoporosis include chronic treatment with glucocorticoids, gastrointestinal disorders, diabetes mellitus (T1D, T2D), rheumatoid arthritis, liver disease, gluten enteropathy, multiple myeloma and other hematologic disorders.
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