What is the role of Dkk?
What is the role of Dkk?
Dkks play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero–posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer’s disease.
How is dkk1 secreted?
DKK-1 is a central regulator of osteoblast activity and osteoblastic bone metastasis and is likely dually dependent on the downregulation of microenvironment DKK-1 secretion from: (1) osteoblasts via tumor-produced ET-1; and (2) prostate cancer cells themselves.
What does Wnt stand for in biology?
Wingless-related integration site
The name Wnt is a portmanteau of int and Wg and stands for “Wingless-related integration site”. Wnts are secreted factors that regulate cell growth, motility, and differentiation during embryonic development. Wnts act in a paracrine fashion by activating diverse signaling cascades inside the target cells.
Is Wnt AG protein?
Our data indicate that Gα proteins are not part of the core Wnt/β-catenin signaling pathway and are not generally required for pathway transduction. Gα proteins are not required for Wnt/β-catenin signaling.
Which transcriptional regulatory protein is regulated by Wnt signaling?
β-catenin
In Wnt signalling, LATS2, independent of its kinase ability, can target the interaction between β-catenin and BCL9 to inactivate downstream transcription activity [90].
Where is Wnt released from?
Further studies have shown that Wnt proteins are released on exosomes in mammalian cells as well as in cultured Drosophila cells and epithelial tissues (Gross et al., 2012; Beckett et al., 2013).
Is Wnt a morphogen?
Morphogens are diffusible signalling molecules that pattern cellular fields by setting up differential gene expression in a concentration-dependent manner. Members of the Wnt family of signalling molecules are generally considered to be classical morphogens.
