At what percentage starch can be used as Disintegrant?

At what percentage starch can be used as Disintegrant?

In the pharmaceutical industry, starch is employed as a binder, diluent, and disintegrant. Freshly prepared starch paste at a concentration of 5–20% is routinely used during tablet manufacture (4). At 5–15% concentration, starch finds its applicability as a disintegrant in a number of tablet formulations (5).

What is the difference between starch and pregelatinized starch?

An alternative to native corn starch or polymers for wet granulations is pregelatinized starch. This is a starch that has been previously gelatinized and dried to powder form. Partially pregelatinized starches on the other hand, have a mixture of properties of both native and fully gelatinized starches.

What is maize starch used for in tablets?

Starch is one of the most traditional excipients used for solid dosage formulations. Depending on the application, maize starch acts as a diluent, disintegrant or binder. Native starch is a classic tablet disintegrant whereas pregelatinised starch is often used as a binder.

What is pregelatinized starch used for?

Pregelatinized starch is widely used as a pharmaceutical aid, especially as a filler-binder. It is known that the tableting performance of excipients could be affected by their source.

Is starch a good disintegrant?

Starch is also one of the most commonly used tablet disintegrants at concentrations of 3–15% w/w. However, unmodified starch does not compress well and tends to increase tablet friability and capping if used in high concentrations.

What is disintegrating agent?

Disintegrating agents or disintegrators or disintegrants are the substances which are added to an oral solid dosage form such as tablet, beads, pellet, granule as well as capsule to promote its rapid disintegration or break down into small particles after administration for facilitating rapid dissolution into GI fluid.

How is sodium starch glycolate made?

Sodium starch glycolate is the sodium salt of carboxymethyl ether. It is white to off-white, odorless, tasteless, and free-flowing powder. It is produced by cross-linking and carboxy methylation of potato starch. It can also be manufactured from other starch foods such as corn, wheat, and rice.

Why is maize starch used in paracetamol?

tensile strength (T) and brittle fracture index (BFI) of the paracetamol tablets were affected by pregelatinization of the starch. The results suggest that pregelatinized starches may be useful as binders when a particular degree of bond strength and brittleness is desired.

Is starch a good binder?

As a result of its partial cold water solubility, starch functions exceptionally well in tablet manufacture by wet granulation applications and performs dual functions of both a disintegrant and a binder. In capsule filling processes, Starch function as effective binders.

What are the pharmaceutical uses of starch?

Starches are typically derived from corn or potato. Starches are used in the pharmaceutical industry for a wide variety of reasons, such as an excipient, a tablet and capsule diluent, a tablet and capsule disintegrant, a glidant, or as binder.

Is starch a pregelatinized?

Pregelatinized starch is highly digestible starch derived from corn, potato, arrowroot and wheat flour. Pregelatinized starch is pre-cooked, dried, and ground for use in various industries. Pregelatinized starch is obtained in flake and powder form which allow products to develop viscosity.

What is the difference between starch 1500 g and 1500 lm?

Starch 1500: Meets PhEur and USP/NF specifications for pregelatinized starch. Starch 1500 LM: Low moisture product (less than 7% moisture). Meets PhEur and USP/NF specifications for pregelatinized starch. Starch 1500 G: Meets PhEur and USP/NF specifications for pregelatinized starch and JPE requirements for partly pregelatinized starch.

What types of starch does colorcolorcon supply?

Colorcon supplies three types of pregelatinized starch. Starch 1500 products are designed to meet regulatory needs worldwide, especially PhEur and USP/NF specifications . Starch 1500 LM has a low moisture content (less than 7% moisture). Starch 1500 G meets PhEur and USP/NF specifications for pregelatinized

What is co-Processed starch excipient used for?

Provides excellent stability for moisture sensitive drugs and cost eu001eective content uniformity as a carrier for low dose APIs. StarCap 1500® co-processed starch excipient is a mix of globally accepted excipients (corn starch and pregelatinized starch) designed for use in capsules and tablets.

What is pregelatinized starch?

Pregelatinized starch is obtained from corn, waxy corn, potato or tapioca enhances flow and compressibility which tends to used as binder in many applications. Commercially, Pregelatinized Starch are available in fully and partially Pregelatinized starch grades depending on the degree of starch gelatinization.