Can doxorubicin cause extravasation injury?

Can doxorubicin cause extravasation injury?

Doxorubicin is one of the most widely used drugs and hence has the highest potential and risk for extravasation, and, therefore, dexrazoxane should be made available at all centers that administer anthracyclines chemotherapy.

What gives doxorubicin its red color?

People often experience red discoloration of the urine for a few days. Doxorubicin is in the anthracycline and antitumor antibiotic family of medications. It works in part by interfering with the function of DNA….Doxorubicin.

Clinical data
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CAS Number 23214-92-8
PubChem CID 31703

Which of the following symptoms can indicate that an extravasation of a peripheral administration of chemotherapy has occurred?

Signs and symptoms of vesicant extravasation include swelling, redness and/or discomfort that is often described as a burning or stinging sensation.

How is extravasation treated?

At the first sign of extravasation, the following steps are recommended: (1) stop administration of IV fluids immediately, (2) disconnect the IV tube from the cannula, (3) aspirate any residual drug from the cannula, (4) administer a drug-specific antidote, and (5) notify the physician (Fig.

How do you deal with extravasation?

If extravasation occurs, the injection should be stopped immediately and the IV tubing disconnected. Avoid applying pressure to the site, and do not flush the line. Leave the original catheter in place, and attempt to aspirate as much of the infiltrated drug as possible.

How is doxorubicin manufactured?

Doxorubicin is classified as an antitumor antibiotic. Antitumor antibiotics are made from natural products produced by species of the soil fungus Streptomyces. These drugs act during multiple phases of the cell cycle and are considered cell-cycle specific.

How do you manage extravasation?

What is the generic name for doxorubicin?

Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®.

What is the absorption spectrum of doxorubicin in PBS?

Absorption spectra of Doxorubicin in both, PBS and PVA film, are located in a visible spectral region with maximum of about 500 nm (Fig. 1). In PVA film a vibronic structure of the spectrum is slightly more visible than in PBS.

What are the side effects of doxorubicin extravasation?

Extravasation of conventional doxorubicin produces severe local tissue necrosis, as well as possible cellulitis, vesication, thrombophlebitis, lymphangitis, or painful induration and may result in limitation of mobility of the adjacent joints.

What is the fluorescence emission of doxorubicin in PVA film?

In PVA film the fluorescence anisotropy is about 0.30 whereas in the saline buffer only 0.07. Quantum efficiencies of Doxorubicin were compared to a known standard Rhodamine 101 which has fluorescence emission in a similar spectral region.

What is the difference between daunorubicin and doxorubin?

Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis.

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