Can lambda light chains fluctuate?
Can lambda light chains fluctuate?
The example shown in the table below illustrated how change in FLC ratio at each time point can be quite large, although the involved kappa chain concentration does not change at all and the uninvolved lambda chain concentration only fluctuates slightly within the normal range.
Why is my Kappa Lambda ratio high?
26-‐1.65 The ratio of kappa to lambda is an important indicator. When one level (kappa or lambda)is high and the other is low, this is an indication that myeloma is active. If both kappa and lambda are increased, it can show a disease other than myeloma (like kidney disease).
What causes kappa light chains to increase?
Elevated kappa and lambda (K/L) free light chain (FLC) may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance. A specific increase in FLC (eg, FLC K:L ratio) must be demonstrated for diagnostic purposes.
What is considered a high Kappa Lambda ratio?
In general, a low kappa-lambda ratio (< 0.26) indicates the overproduction of lambda light chains, and a high ratio (> 1.65) indicates the overproduction of kappa light chains.
What is a bad Kappa Lambda ratio?
Normal range: 0.26-1.65. An abnormal kappa/lambda ratio may indicate excess production of the kappa or lambda light chain due to multiple myeloma.
What does a high Kappa/Lambda ratio mean?
An abnormal kappa-lambda FLC ratio indicates an excess of one light chain type versus the other, and is interpreted as a surrogate for clonal expansion based on extensive testing in healthy volunteers, and patients with myeloma, amyloidosis, and renal dysfunction.
What causes elevated Kappa free light chains?
The elevated kappa light chains ‘can’ be associated with multiple myeloma, BUT it can also be related to a very BENIGN condition called monoclonal gammopathy of undetermined significance (MGUS).
What does a high free Kappa/Lambda ratio mean?
FREE KAPPA/LAMBDA RATIO * .26-1.65 The ratio of kappa to lambda is an important indicator. When one level (kappa or lambda)is high and the other is low, this is an indication that myeloma is active. If both kappa and lambda are increased, it can show a disease other than myeloma (like kidney disease).
What does elevated kappa light chains mean?
Cautions. Elevated kappa and lambda (K/L) free light chain (FLC) may occur due to polyclonal hypergammaglobulinemia or impaired renal clearance. A specific increase in FLC (eg, FLC K:L ratio) must be demonstrated for diagnostic purposes. Moderate-to-marked lipemia may interfere with the ability to perform testing.
