Can lipitor cause rhabdomyolysis?

Can lipitor cause rhabdomyolysis?

However, the risk of developing rhabdomyolysis from statin therapy is very low, around 1.5 for each 100,000 people taking statins. Rhabdomyolysis or milder forms of muscle inflammation from statins can be diagnosed with a blood test measuring levels of the enzyme creatinine kinase.

Which medications are associated with rhabdomyolysis?

Which medications may cause rhabdomyolysis?

• Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors)
• Antihistamines (particularly in children)
• Salicylates.
• Caffeine.
• Fibric acid derivatives (eg, bezafibrate, clofibrate, fenofibrate, and gemfibrozil)
• Neuroleptics/antipsychotics.

Which statin is associated with the lowest risk of rhabdomyolysis?

Fluvastatin, pravastatin and rosuvastatin may be considered as alternatives as they are not as extensively metabolized by CYP3A4 and therefore less likely to result in rhabdomyolysis but still require careful monitoring [9].

How do statins cause rhabdomyolysis?

Rhabdomyolysis is a severe form of myopathy. Lipophilic statins, such as atorvastatin, simvastatin, and fluvastatin, increase cell disruption through apoptosis and proteolysis. These statins can easily pass through the lipid layer membrane by passive transport; thus, they have higher toxic effects.

Which statins are more likely to cause rhabdomyolysis?

Statin drugs and dosages Simvastatin was the most common statin medication reported in association with rhabdomyolysis (55 cases), most commonly taken at a dose of 40 mg/day. Atorvastatin was the second most common drug (20 cases), used in doses of 10 mg/day.

Can lipitor cause muscle damage?

Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins.

Which statin has the highest incidence of rhabdomyolysis?

What medications can cause myositis?

Drugs causing myositis or myopathy include:

• Statins.
• Colchicine.
• Plaquenil (hydroxychloroquine)
• Alpha-interferon.
• Cocaine.
• Alcohol.

Which statin is associated with the highest risk of rhabdomyolysis?

Can lipitor cause high CK levels?

Statins can magnify exercise-induced marked elevation of the CK.

How do you know if you have muscle damage from statins?

One of the most common complaints of people taking statins is muscle pain. You may feel this pain as a soreness, tiredness or weakness in your muscles. The pain can be a mild discomfort, or it can be severe enough to make your daily activities difficult.

Is muscle damage from statins reversible?

The damage is typically reversible once the person stops taking the statin. More rarely still, a severe type of muscle damage called rhabdomyolysis may occur, in an estimated 2–3 in 100,000 people taking this type of drug per year.